Paternal age at birth and high-functioning autistic-spectrum disorder in offspring
| Autor: | Kenji J. Tsuchiya, Nori Takei, Shiro Suda, Atsuko Yagi, Toshirou Sugiyama, Masayoshi Kawai, Genichi Sugihara, Kazuhiko Nakamura, Kimie Iwaki, Hideo Matsuzaki, Yoshimoto Sekine, Norio Mori, Kaori Matsumoto, Shu Takagai, Taishi Miyachi, Katsuaki Suzuki, Yasuhide Iwata, Masatsugu Tsujii |
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| Rok vydání: | 2008 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent Offspring Intelligence Paternal Age 03 medical and health sciences Young Adult 0302 clinical medicine Sex Factors Risk Factors Intellectual disability medicine Humans 030212 general & internal medicine Young adult Risk factor Autistic Disorder Psychiatry Child Case-control study Odds ratio medicine.disease 030227 psychiatry Developmental disorder Psychiatry and Mental health Birth order Phenotype Case-Control Studies Child Preschool Female Psychology Demography Maternal Age |
| Zdroj: | The British journal of psychiatry : the journal of mental science. 193(4) |
| ISSN: | 1472-1465 |
| Popis: | BackgroundPrevious studies have reported the association between advanced paternal age at birth and the risk of autistic-spectrum disorder in offspring, including offspring with intellectual disability.AimsTo test whether an association between advanced paternal age at birth is found in offspring with high-functioning autistic-spectrum disorder (i.e. offspring without intellectual disability).MethodA case–control study was conducted in Japan. The participants consisted of individuals with full-scale IQ ⩾ 70, with a DSM–IV autistic disorder or related diagnosis. Unrelated healthy volunteers were recruited as controls. Parental ages were divided into tertiles (i.e. three age classes). Odds ratios and 95% confidence intervals were estimated using logistic regression analyses, with an adjustment for age, gender and birth order.ResultsEighty-four individuals with autistic-spectrum disorder but without intellectual disability and 208 healthy controls were enrolled. Increased paternal, but not maternal, age was associated with an elevated risk of high-functioning autistic-spectrum disorder. A one-level advance in paternal age class corresponded to a 1.8-fold increase in risk, after adjustment for covariates.ConclusionsAdvanced paternal age is associated with an increased risk for high-functioning autistic-spectrum disorder. |
| Databáze: | OpenAIRE |
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