Abnormal platelet lipid membrane composition in pregnancy induced hypertension
| Autor: | E. V. Cosmi, G. Coata, T Frusca, G. C. Di Renzo, M.M. Anceschi, D Baranzelli |
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| Rok vydání: | 1992 |
| Předmět: |
Blood Platelets
medicine.medical_specialty Pregnancy Complications Cardiovascular Preeclampsia Membrane Lipids chemistry.chemical_compound Pregnancy Internal medicine medicine Humans Platelet Lipid bilayer Abnormal Platelet Proteinuria Cholesterol business.industry Obstetrics and Gynecology medicine.disease Pathophysiology Endocrinology chemistry Hypertension Pediatrics Perinatology and Child Health Gestation Female medicine.symptom business |
| Zdroj: | jpme. 20:123-127 |
| ISSN: | 1619-3997 0300-5577 |
| DOI: | 10.1515/jpme.1992.20.2.123 |
| Popis: | The cholesterol:phospholipid ratio (C/PL) was measured in platelet plasma membrane in patients with pregnancy-induced hypertension [with proteinuria (PE), and without proteinuria (PIH)] and in matched normotensive gestational controls (NT). The C/PL was raised in the platelet membrane from PE (1.52 +/- 0.50, 95% CI 1.13 to 1.90) and PIH (1.38 +/- 0.34, 95% CI 1.08 to 1.67) compared with that from NT controls (0.88 +/- 0.13, 95% CI 0.80 to 0.95) (p less than 0.01, ANOVA test). No correlation was found when C/PL was regressed against total serum cholesterol levels. The abnormality of lipid composition of the platelet plasma membrane could account for some of the changes in platelet function that have been described in PIH. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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