The microglial NLRP3 inflammasome is involved in human SARS-CoV-2 cerebral pathogenicity: A report of three post-mortem cases

Autor:	Daisy Sanchez, Emilio F. Acosta, Daina Cremata-García, Giselle Pentón-Rol, Beatriz Piniella-Matamoros, Nelson Acosta-Rivero, Leonardo Oramas Díaz, Gerardo Guillen-Nieto, Briandy Fernández-Marrero, Eduardo Pentón-Arias, Viviana Falcón Cama, Nathalie Gilva-Rodríguez, Ana Victoria Casadesús, Angelina Díaz, Majel Cervantes-Llanos, Javier Marín-Prida, Teresita Montero-González, Israel Borrajero, Leticia del Rosario-Cruz, Yorexis González
Rok vydání:	2021
Předmět:	Nervous system Male Pathology medicine.medical_specialty Inflammasomes viruses Short Communication Immunology Biology Human brain CNS central nervous system NLR Family Pyrin Domain-Containing 3 Protein medicine Immunology and Allergy Humans ACE2 Angiotensin-Converting Enzyme 2 Receptor Nucleocapsid Aged COVID-19 coronavirus disease 2019 Aged 80 and over Neurons Lung Microglia SARS-CoV-2 Macrophages Viral nucleocapsid Colocalization Brain COVID-19 Inflammasome NLRP3 inflammasome Oligodendroglia medicine.anatomical_structure NC nucleocapsid Neurology Astrocytes Female Neurology (clinical) Autopsy SARS-CoV-2 severe acute respiratory syndrome coronavirus-2 medicine.drug
Zdroj:	Journal of Neuroimmunology
ISSN:	1872-8421
Popis:	We herein report, by using confocal immunofluorescence, the colocalization of the SARS-CoV-2 nucleocapsid within neurons, astrocytes, oligodendrocytes and microglia in three deceased COVID-19 cases, of between 78 and 85 years of age at death. The viral nucleocapsid was detected together with its ACE2 cell entry receptor, as well as the NLRP3 inflammasome in cerebral cortical tissues. It is noteworthy that NLRP3 was colocalized with CD68 + macrophages in the brain and lung of the deceased, suggesting the critical role of this type of inflammasome in SARS-CoV-2 lesions of the nervous system/lungs and supporting its potential role as a therapeutic target. Graphical abstract Unlabelled Image
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de2c5df79c393b7e9846d51c6ca2a334 https://pubmed.ncbi.nlm.nih.gov/34619427 Zobrazit plný text záznamu Full Text from ScienceDirect