Unpacking common and distinct neuroanatomical alterations in cocaine dependent versus pathological gambling
| Autor: | Patricia Irizar, José Miguel Martínez-González, Natalia Albein-Urios, Valentina Lorenzetti, Antonio Verdejo-García |
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| Rok vydání: | 2019 |
| Předmět: |
Adult
Male Dopamine Decision Making Inferior frontal gyrus Craving Striatum Neuropsychological Tests Amygdala Cocaine dependence 03 medical and health sciences Cocaine-Related Disorders 0302 clinical medicine inferior frontal gyrus Reward Functional neuroimaging medicine Humans Pharmacology (medical) Biological Psychiatry Pharmacology Brain Mapping business.industry Functional Neuroimaging pathological gambling Brain medicine.disease Magnetic Resonance Imaging 030227 psychiatry pre-frontal cortex Psychiatry and Mental health Inhibition Psychological medicine.anatomical_structure cocaine dependence Neurology Gambling Orbitofrontal cortex Female Neurology (clinical) medicine.symptom business Insula Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. 33 |
| ISSN: | 1873-7862 |
| Popis: | Pathological gambling and cocaine dependence are highly pervasive disorders. Functional neuroimaging evidence implicates aberrant activity of prefrontal striatal pathways in both disorders. It is unclear if the neuroanatomy of these areas is also affected. Participants with pathological gambling (n = 18), cocaine dependence (n = 19) and controls (n = 21) underwent high-resolution structural MRI scan and cognitive assessments. In line with emerging functional neuroimaging findings, we hypothesised (i) lower volumes of corticostriatal areas ascribed to decision-making/inhibitory control, craving and reward processing (i.e., orbitofrontal cortex, inferior frontal gyrus, amygdala, striatum, insula) in both pathological gamblers and cocaine dependent participants versus controls; (ii) selected dopaminergic/glutamatergic pathways directly taxed by cocaine (i.e., superior, dorsolateral and anterior cingulate cortices) would be altered in cocaine dependent versus control participants only. Analyses were conducted with a bonferroni correction. Our results showed that both pathological gambling and cocaine dependent participants, compared to controls, had larger volumes of the right inferior frontal gyrus (ps |
| Databáze: | OpenAIRE |
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