In Vitro Activities of the New Antitubercular Agents PA-824 and BTZ043 against Nocardia brasiliensis
| Autor: | Norma Alejandra Gonzalez-Martinez, Lucio Vera-Cabrera, Jorge Ocampo-Candiani, Stewart T. Cole, Mayra Paola Campos-Rivera |
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| Rok vydání: | 2012 |
| Předmět: |
Pharmacology
biology Nocardia brasiliensis Antitubercular Agents Nocardia Microbial Sensitivity Tests biology.organism_classification In vitro Microbiology Mycobacterium tuberculosis Infectious Diseases Nitroimidazoles Susceptibility Mycobacterium-Tuberculosis In vivo Mic values Pharmacology (medical) |
| Zdroj: | Antimicrobial Agents and Chemotherapy. 56:3984-3985 |
| ISSN: | 1098-6596 0066-4804 |
| DOI: | 10.1128/aac.00115-12 |
| Popis: | The in vitro activity of PA-824 and BTZ043 against 30 Nocardia brasiliensis isolates was tested. The MIC 50 and MIC 90 values for PA-824 were both >64 μg/ml. The same values for BTZ043 were 0.125 and 0.250 μg/ml. Given the MIC values for benzothiazinone (BTZ) compounds, we consider them good candidates to be tested in vivo against N. brasiliensis . |
| Databáze: | OpenAIRE |
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