The intravaginal application of misoprostol improves induction of abortion with aglepristone

Autor: Ali Reha Ağaoğlu, Birten Emre, Selim Aslan, Duygu Kaya, Nilgün Gültiken, Armağan Çolak, İbrahim Küçükaslan, B.S. Mulazımoglu, Sabine Schäfer-Somi
Přispěvatelé: Ondokuz Mayıs Üniversitesi
Rok vydání: 2011
Předmět:
Zdroj: Theriogenology. 76:74-82
ISSN: 0093-691X
DOI: 10.1016/j.theriogenology.2011.01.019
Popis: Kucukaslan, Ibrahim/0000-0002-3458-4409 WOS: 000291843300008 PubMed: 21458052 The aim of the present study was to compare the clinical and endocrinological effects of four different treatments for the induction of abortion in bitches. For this purpose, 28 pregnant bitches between days 25 and 35 of gestation, were randomly assigned to four groups. In group I (n = 7), only aglepristone (AGL, 10mg/kg bw, two injections 24 h apart, s.c.) was administered. In group II (n = 7), AGL (as in group I), cabergolin (CAB, 5 mu g/kg, daily p.o., until completion of abortion) and misoprostol (MIS, 200 mu g for bitches with 20 kg bw, daily intravaginally, until completion of abortion) were administered. In group III (n = 7), AGL (as in group I) and MIS (as in group II) were administered. In group IV (n = 7) AGL, (as in group I) and cloprostenol (CLO, 1 mu g/kg bw, s.c., two injections 24 h apart with the AGL injections) were combined. In all groups, bitches were examined daily, clinically and ultrasonographically to monitor resorptions/abortions. To measure serum progesterone (P4) and total estrogen (FE) concentrations, blood samples were collected in all groups immediately after the first AGL administration and every other day until completion of abortion. No statistical differences were found between groups concerning the duration until completion of abortion following treatment (n.s.); however, in Group III, 6 d after the start of treatment all pregnancies were terminated whereas in Group I, II and IV, only 57.1% (417), 85.7 % (617) and 42.8 % (317) of pregnancies were terminated. In the latter groups, all pregnancies were terminated between days 8 and 10 after the start of treatment In Group IV, P4 concentrations on days two and one before the beginning of abortion and the day the abortion started was significantly lower than in the other groups (P < 0.01). No statistical differences were found between groups for TE concentrations (P > 0.05). In Groups I, II and III, no severe side effects occurred. Severe vomiting after each treatment and until the end of abortion was observed in Group IV only. In conclusion, only when a combination of AGL and MIS was used abortion was completed within 6 d in all bitches whereas the additional use of CAB did not improve the treatment. (C) 2011 Elsevier Inc. All rights reserved.
Databáze: OpenAIRE
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