The effects of interferon on the expression of human papillomavirus oncogenes
| Autor: | Milton W. Taylor, Kelly Y. Kim, Lawrence Blatt |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Genes
Viral Gene Expression Uterine Cervical Neoplasms Interferon alpha-2 law.invention HeLa Interferon-gamma Interferon law Virology Tumor Cells Cultured medicine Humans Human papillomavirus Papillomaviridae Gene Cervical cancer Oncogene biology Interferon-alpha Oncogenes medicine.disease biology.organism_classification Molecular biology Recombinant Proteins female genital diseases and pregnancy complications Cell culture Interferon Type I Recombinant DNA Female Interferons HeLa Cells medicine.drug |
| Zdroj: | Journal of General Virology. 81:695-700 |
| ISSN: | 1465-2099 0022-1317 |
| DOI: | 10.1099/0022-1317-81-3-695 |
| Popis: | The effects of interferon (IFN)-alpha, IFN-beta and IFN-gamma on human papillomavirus (HPV) oncogene expression were studied in various cervical carcinoma cell lines containing integrated copies of either HPV type 16 or HPV type 18. The levels of E6 and E7 transcripts were examined 6 h and 30 h after treatment with IFN. In HeLa cells, all three classes of IFNs effected a decrease in the level of HPV-18 E6 and E7 transcripts. On the other hand, none of the IFNs altered the level of these transcripts in C-4II cells. Only IFN-gamma decreased the level of HPV-16 E6 and E7 transcripts in CaSki and HPK1A cells, while IFN-gamma actually increased the level of these transcripts in SiHa cells. This differential IFN regulation of HPV expression in various cervical cancer cell lines may account for the contradictory clinical results observed after treatment of cervical cancer with IFN. |
| Databáze: | OpenAIRE |
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