Surface Modification of Electrospun Bioresorbable and Biostable Scaffolds by Pulsed DC Magnetron Sputtering of Titanium for Gingival Tissue Regeneration
| Autor: | Arsalan D. Badaraev, Dmitrii V. Sidelev, Anna I. Kozelskaya, Evgeny N. Bolbasov, Tuan-Hoang Tran, Alexey V. Nashchekin, Anna B. Malashicheva, Sven Rutkowski, Sergei I. Tverdokhlebov |
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| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: |
Polymers and Plastics
модификации импульсное магнетронное распыление pulsed DC magnetron sputtering PLGA General Chemistry titanium coating полимерные каркасы электропрядение gingival fibroblasts постоянный ток титановые покрытия polymer scaffolds plasma surface modification VDF-TeFE electrospinning |
| Zdroj: | Polymers Polymers; Volume 14; Issue 22; Pages: 4922 |
| Popis: | In this study, polymer scaffolds were fabricated from biodegradable poly(lactide-co-glycolide) (PLGA) and from non-biodegradable vinylidene fluoride-tetrafluoroethylene (VDF-TeFE) by electrospinning. These polymer scaffolds were subsequently surface-modified by sputtering titanium targets in an argon atmosphere. Direct current pulsed magnetron sputtering was applied to prevent a significant influence of discharge plasma on the morphology and mechanical properties of the nonwoven polymer scaffolds. The scaffolds with initially hydrophobic properties show higher hydrophilicity and absorbing properties after surface modification with titanium. The surface modification by titanium significantly increases the cell adhesion of both the biodegradable and the non-biodegradable scaffolds. Immunocytochemistry investigations of human gingival fibroblast cells on the surface-modified scaffolds indicate that a PLGA scaffold exhibits higher cell adhesion than a VDF-TeFE scaffold. |
| Databáze: | OpenAIRE |
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