Lymphocyte cell counts in middle age are positively associated with subsequent all-cause and cardiovascular mortality
| Autor: | Mark T. Drayson, Douglas Carroll, Ashley S. Phillips, Catharine R. Gale, G. D. Batty |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Adult
Male medicine.medical_specialty Lymphocyte B-Lymphocyte Subsets Veterans Health R Medicine (General) Gastroenterology Cohort Studies Predictive Value of Tests T-Lymphocyte Subsets Cause of Death Internal medicine medicine Humans Lymphocyte Count Prospective Studies GV Recreation Leisure Survival analysis Proportional Hazards Models Veterans Cause of death business.industry Proportional hazards model Hazard ratio General Medicine T lymphocyte Middle Aged Flow Cytometry Survival Analysis Confidence interval medicine.anatomical_structure Cardiovascular Diseases Immunology Cohort business |
| Zdroj: | QJM. 104:319-324 |
| ISSN: | 1460-2393 1460-2725 |
| DOI: | 10.1093/qjmed/hcq199 |
| Popis: | Background: There is an association between higher white blood cell counts and all-cause and cardiovascular disease (CVD) mortality. However, little is known about the prognostic significance of circulating lymphocyte and lymphocyte subset numbers. Aims: The present study examined the association between T-, CD4-, CD8- and B-cell numbers, and the CD4:CD8 ratio, and all-cause and CVD mortality. Methods: Lymphocyte and lymphocyte subset numbers were measured by flow cytometry in a cohort of 4256 male middle-aged Vietnam-era US veterans. Mortality was tracked for 15 years and cause of death was determined from death certificates. Results: In fully adjusted survival analyses, high circulating T-cells numbers were associated with increased risk of both all-cause [hazard ratio (HR)?=?1.75, 95% confidence interval (CI) 1.15–2.66] and cardiovascular (HR?=?3.57, 95% CI 1.53–8.33) mortality. The former association appeared to reflect an effect for high CD8-cells numbers, the latter an effect for high CD4-cell numbers. For all-cause mortality, a high CD4:CD8 ratio was protective (HR?=?0.58, 95% CI 0.41–0.81). Cardiovascular mortality was also predicted by high B-cells numbers (HR?=?1.87, 95% CI 1.10–3.17). Conclusion: Circulating lymphocyte and lymphocyte subset numbers may have substantial prognostic significance for both all-cause and CVD mortality. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|