Chronic kidney disease epidemiology collaboration-derived glomerular filtration rate performs better at detecting preclinical end-organ changes than alternative equations in black Africans
| Autor: | Patrick H Dessein, Pinhas Sareli, Hendrik L. Booysen, Andrew R. Raymond, Hon-Chun Hsu, Angela J. Woodiwiss, Gavin R. Norton |
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| Přispěvatelé: | Clinical sciences |
| Rok vydání: | 2016 |
| Předmět: |
Male
Pathology Epidemiology Physiology 030232 urology & nephrology 030204 cardiovascular system & hematology urologic and male genital diseases Left ventricular hypertrophy Carotid Intima-Media Thickness Muscle hypertrophy South Africa chemistry.chemical_compound 0302 clinical medicine Chronic Kidney Disease Pulse wave velocity Medicine(all) Organ Size Middle Aged female genital diseases and pregnancy complications Echocardiography Area Under Curve Creatinine cardiovascular system Cardiology Female Hypertrophy Left Ventricular Cardiology and Cardiovascular Medicine Glomerular Filtration Rate Adult medicine.medical_specialty EGFR Black People Renal function Pulse Wave Analysis 03 medical and health sciences Internal medicine Internal Medicine medicine Humans Renal Insufficiency Chronic Receiver operating characteristic business.industry Body Weight Mathematical Concepts medicine.disease ROC Curve chemistry Lean body mass business Kidney disease |
| Zdroj: | Journal of Hypertension. 34:1178-1185 |
| ISSN: | 0263-6352 |
| Popis: | AIM: To identify whether the more recently developed equation for estimated glomerular filtration rate (eGFR) [Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI)] is more closely associated with end-organ changes than previous equations in a group of black African descent. METHODS: In 1221 randomly recruited participants of black African ancestry in South Africa, we evaluated serum creatinine concentrations, echocardiographic left ventricular mass index (n = 833), carotid-femoral (aortic) pulse wave velocity (PWV) (n = 1053) and carotid intima-media thickness (n = 633). We calculated eGFR from the Jelliffe, five Cockcroft-Gault, Salazar-Corcoran, Modification of Diet in Renal Disease (MDRD) and CKD-EPI equations. RESULTS: After multivariate adjustments, eGFR calculated from all formulae was inversely associated with left ventricular mass index (P 0.08). However, although eGFR determined from all equations except Cockcroft-Gault lean body weight or adjusted body weight was independently associated with left ventricular hypertrophy (n = 390 of 833), CKD-EPI-derived eGFR, but not eGFR determined from alternative equations, was independently associated with an increased PWV (n = 88 of 1053). eGFR derived from the CKD-EPI and MDRD equations showed a better performance (area under the receiver operator characteristic curve) for the detection of left ventricular hypertrophy (P |
| Databáze: | OpenAIRE |
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