Microstructural and mechanical characterization of scarred vocal folds
| Autor: | Nageswara R. Ghattamaneni, Amir K. Miri, Luc Mongeau, Nicole Y. K. Li, Susan L. Thibeault, Paul W. Wiseman, Hossein K. Heris |
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| Rok vydání: | 2015 |
| Předmět: |
Male
Area fraction Materials science Biomedical Engineering Biophysics Pilot Projects Vocal Cords Microscopy Atomic Force Models Biological Article Collagen fibril Rats Sprague-Dawley Cicatrix Indentation medicine Animals Orthopedics and Sports Medicine Elasticity (economics) Mechanical Phenomena Lamina propria Microscopy Confocal Atomic force microscopy Rehabilitation Fold (geology) Anatomy Models Theoretical Elasticity Biomechanical Phenomena Rats medicine.anatomical_structure Vocal folds Models Animal Collagen |
| Zdroj: | Journal of Biomechanics. 48:708-711 |
| ISSN: | 0021-9290 |
| DOI: | 10.1016/j.jbiomech.2015.01.014 |
| Popis: | The goal of this study was to characterize the vocal folds microstructure and elasticity using nonlinear laser scanning microscopy and atomic force microscopy-based indentation, respectively. As a pilot study, the vocal folds of fourteen rats were unilaterally injured by full removal of lamina propria; the uninjured folds of the same animals served as controls. The area fraction of collagen fibrils was found to be greater in scarred tissues two months after injury than the uninjured controls. A novel mathematical model was also proposed to relate collagen concentration and tissue bulk modulus. This work presents a first step towards systematic investigation of microstructural and mechanical characteristics in scarred vocal fold tissue. |
| Databáze: | OpenAIRE |
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