Carotid β-stiffness index is associated with slower processing speed but not working memory or white matter integrity in healthy middle-aged/older adults
| Autor: | James D. Kent, Michelle W. Voss, Kaitlyn Dubishar, Gary L. Pierce, Lyndsey E. DuBose, Phillip G. Schmid, Gardar Sigurdsson, Timothy B. Weng, Abbi D. Lane-Cordova, Patrick B. Barlow |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
musculoskeletal diseases
Male Aging medicine.medical_specialty animal structures Physiology macromolecular substances 030204 cardiovascular system & hematology Body Mass Index White matter Young Adult 03 medical and health sciences Cognition Vascular Stiffness 0302 clinical medicine Physiology (medical) Internal medicine medicine Humans Effects of sleep deprivation on cognitive performance Stroke Pulse wave velocity Working memory business.industry technology industry and agriculture Middle Aged equipment and supplies medicine.disease White Matter Frontal Lobe Carotid Arteries Memory Short-Term medicine.anatomical_structure Arterial stiffness Cardiology Female Aortic stiffness business Body mass index 030217 neurology & neurosurgery Research Article Compliance |
| Zdroj: | Journal of Applied Physiology. 122:868-876 |
| ISSN: | 1522-1601 8750-7587 |
| Popis: | Aging is associated with increased carotid artery stiffness, a predictor of incident stroke, and reduced cognitive performance and brain white matter integrity (WMI) in humans. Therefore, we hypothesized that higher carotid stiffness/lower compliance would be independently associated with slower processing speed, higher working memory cost, and lower WMI in healthy middle-aged/older (MA/O) adults. Carotid β-stiffness ( P < 0.001) was greater and compliance ( P < 0.001) was lower in MA/O ( n = 32; 64.4 ± 4.3 yr) vs. young ( n = 19; 23.8 ± 2.9 yr) adults. MA/O adults demonstrated slower processing speed (27.4 ± 4.6 vs. 35.4 ± 5.0 U/60 s, P < 0.001) and higher working memory cost (−15.4 ± 0.14 vs. −2.2 ± 0.05%, P < 0.001) vs. young adults. Global WMI was lower in MA/O adults ( P < 0.001) and regionally in the frontal lobe ( P = 0.020) and genu ( P = 0.009). In the entire cohort, multiple regression analysis that included education, sex, and body mass index, carotid β-stiffness index (B = −0.53 ± 0.15 U, P = 0.001) and age group (B = −4.61 ± 1.7, P = 0.012, adjusted R2 = 0.4) predicted processing speed but not working memory cost or WMI. Among MA/O adults, higher β-stiffness (B = −0.60 ± 0.18, P = 0.002) and lower compliance (B = 0.93 ± 0.26, P = 0.002) were associated with slower processing speed but not working memory cost or WMI. These data suggest that greater carotid artery stiffness is independently and selectively associated with slower processing speed but not working memory among MA/O adults. Carotid artery stiffening may modulate reductions in processing speed earlier than working memory with healthy aging in humans. NEW & NOTEWORTHY Previously, studies investigating the relation between large elastic artery stiffness, cognition, and brain structure have focused mainly on aortic stiffness in aged individuals with cardiovascular disease risk factors and other comorbidities. This study adds to the field by demonstrating that the age-related increases in carotid artery stiffness, but not aortic stiffness, is independently and selectively associated with slower processing speed but not working memory among middle-aged/older adults with low cardiovascular disease risk factor burden. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|