Cells under pressure
| Autor: | Dhiraj Indana, Ovijit Chaudhuri |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
tumor Materials science multicellular aggregates Mouse QH301-705.5 extracellular matrix Science Physics of Living Systems General Biochemistry Genetics and Molecular Biology Extracellular matrix 03 medical and health sciences 0302 clinical medicine Cell Movement Cell Line Tumor medicine cancer composite Solid stress Biology (General) Cell Proliferation Mechanical Phenomena General Immunology and Microbiology General Neuroscience mechanical stress Cancer General Medicine Compression (physics) medicine.disease compression poro-active 030104 developmental biology Cancer cell Biophysics Medicine 030217 neurology & neurosurgery Research Article |
| Zdroj: | eLife, Vol 10 (2021) eLife |
| Popis: | Imposed deformations play an important role in morphogenesis and tissue homeostasis, both in normal and pathological conditions. To perceive mechanical perturbations of different types and magnitudes, tissues need appropriate detectors, with a compliance that matches the perturbation amplitude. By comparing results of selective osmotic compressions of CT26 mouse cells within multicellular aggregates and global aggregate compressions, we show that global compressions have a strong impact on the aggregates growth and internal cell motility, while selective compressions of same magnitude have almost no effect. Both compressions alter the volume of individual cells in the same way over a shor-timescale, but, by draining the water out of the extracellular matrix, the global one imposes a residual compressive mechanical stress on the cells over a long-timescale, while the selective one does not. We conclude that the extracellular matrix is as a sensor that mechanically regulates cell proliferation and migration in a 3D environment. |
| Databáze: | OpenAIRE |
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