Comparison of two strategies for the treatment of radiogenic leukopenia using granulocyte colony stimulating factor
| Autor: | H. von Lieven, B. Rosskopf, I.A. Adamietz, F.D. Dapper, H.D. Boettcher |
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| Rok vydání: | 1996 |
| Předmět: |
Adult
Male Cancer Research medicine.medical_specialty medicine.medical_treatment law.invention Randomized controlled trial law Granulocyte Colony-Stimulating Factor medicine Humans Radiology Nuclear Medicine and imaging Clinical significance Aged Aged 80 and over Radiation Leukopenia Radiotherapy business.industry Middle Aged Recombinant Proteins Surgery Discontinuation Granulocyte colony-stimulating factor Radiation therapy Clinical trial Oncology Anesthesia Female medicine.symptom Complication business |
| Zdroj: | International Journal of Radiation Oncology*Biology*Physics. 35:61-67 |
| ISSN: | 0360-3016 |
| DOI: | 10.1016/s0360-3016(96)85012-7 |
| Popis: | Radiation-induced leukopenia can cause a delay or discontinuation of radiotherapy. This complication can be overcome with the use of granulocyte colony-stimulating factor (G-CSF). However, an uncertainty exists regarding the mode of application of G-CSF in patients treated with radiotherapy. For this reason, the efficacy of two strategies for the administration of G-CSF in irradiated patients was compared in a prospective randomized clinical study.Forty-one patients who developed leukopenia (2.5 x 10(9) per liter) while undergoing radiotherapy were treated with G-CSF at a daily dose of 5 microg/kg. The first group received single injections of G-CSF as required (n = 21). The second group received G-CSF on at least 3 consecutive days (n = 20). An analysis was made of the changes in leukocyte counts, the number of days on which radiotherapy had to be interrupted, and the side effects of growth-factor treatment.An increase in leukocyte values in the peripheral blood was observed in all patients treated with G-CSF. In the group which received G-CSF when required, two injections (range: 1-8) were administered in most cases. In the second group, most of the patients received three injections (range: 3-9). The average duration of therapy interruptions due to leukopenia was 4.8 days (0-28) in the first therapy arm and 2.5 (0-20) in the second arm. The variance in the duration of therapy interruptions between the two groups was not significant (p = 0.2). Radiotherapy had to be terminated in two patients due to thrombocytopenia but the application of G-CSF did not seem to be a reason of decreasing platelet counts.Our results reveal that G-CSF is safe and effective in the treatment of radiation-induced leukopenia regardless of the mode of application. Because the calculated difference related to radiation treatment interruptions has no clinical relevance, both approaches examined in our study appear reasonable. |
| Databáze: | OpenAIRE |
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