Prevalence of Pathogens in Young Children Presenting to Hospital with Diarrhea from Lambaréné, Gabon

Autor: Jeannot Fréjus Zinsou, Christiane Sidonie Mapikou Gouleu, Benjamin Mordmüller, Peter G. Kremsner, Fabrice Lotola Mougeni, Gédéon Prince Manouana, Matthew B. B. McCall, Ayola A. Adegnika, Alvyn Nguema Moure, Philipp Hofmann, Maradona Daouda Agbanrin, Mirabeau Mbong Ngwese, Daniel Eibach, Natalie Byrne, Elsy Nnoh Dansou, Alabi Abraham, Steffen Borrmann, Simon Ategbo, Jean Ronald Edoa, Gedeon Bingoulou Matsougou, Bayode Romeo Adegbite
Přispěvatelé: Graduate School, Infectious diseases, APH - Quality of Care, APH - Global Health
Rok vydání: 2021
Předmět:
Male
Adenoviruses
Adenoviridae Infections
Adenoviridae Infections/epidemiology
lnfectious Diseases and Global Health Radboud Institute for Molecular Life Sciences [Radboudumc 4]
medicine.disease_cause
Cyclospora cayetanensis
Enterotoxigenic Escherichia coli
Rotavirus
Shigella
Child
biology
Coinfection
Cryptosporidium
Protozoan Infections/epidemiology
Articles
Bacterial Infections
Diarrhea
Infectious Diseases
Child
Preschool
Female
medicine.symptom
Human
medicine.medical_specialty
Rotavirus Infections
Virology
Internal medicine
parasitic diseases
medicine
Coinfection/epidemiology
Rotavirus Infections/epidemiology
Humans
Gabon
Preschool
Enteroinvasive Escherichia coli
Gabon/epidemiology
Protozoan Infections
business.industry
Adenoviruses
Human
Infant
Newborn
Infant
Newborn
medicine.disease
biology.organism_classification
Diarrhea/epidemiology
Parasitology
business
Bacterial Infections/epidemiology
Zdroj: American Journal of Tropical Medicine and Hygiene, 105, 1, pp. 254-260
American Journal of Tropical Medicine and Hygiene, 105, 254-260
Am J Trop Med Hyg
American journal of tropical medicine and hygiene, 105(1), 254-260. American Society of Tropical Medicine and Hygiene
ISSN: 0002-9637
Popis: Diarrheal disease is the second most frequent cause of mortality in children younger than 5 years worldwide, causing more than half a million deaths each year. Our knowledge of the epidemiology of potentially pathogenic agents found in children suffering from diarrhea in sub-Saharan African countries is still patchy, and thereby hinders implementation of effective preventative interventions. The lack of cheap, easy-to-use diagnostic tools leads to mostly symptomatic and empirical case management. An observational study with a total of 241 participants was conducted from February 2017 to August 2018 among children younger than 5 years with diarrhea in Lambaréné, Gabon. Clinical and demographic data were recorded, and a stool sample was collected. The samples were examined using a commercial rapid immunoassay to detect Rotavirus/adenovirus, conventional bacterial culture for Salmonella spp., and multiplex real-time PCR for Cryptosporidium spp., Giardia lamblia, Cyclospora cayetanensis, enterotoxigenic Escherichia coli (ETEC), and enteroinvasive Escherichia coli (EIEC)/Shigella. At least one infectious agent was present in 121 of 241 (50%) samples. The most frequently isolated pathogens were EIEC/Shigella and ETEC (54/179; 30.2% and 44/179; 24.6%, respectively), followed by G. lamblia (33/241; 13.7%), Cryptosporidium spp. (31/241; 12.9%), and Rotavirus (23/241; 9.5%). Coinfection with multiple pathogens was observed in 33% (40/121) of the positive cases with EIEC/Shigella, ETEC, and Cryptosporidium spp. most frequently identified. Our results provide new insight into the possible causes of diarrheal disease in the Moyen-Ogooué region of Gabon and motivate further research on possible modes of infection and targeted preventive measures.
Databáze: OpenAIRE
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