Evidence for gene x smoking exposure interactions in a genome-wide linkage screen of asthma and bronchial hyper-responsiveness in EGEA families.: Gene-smoking exposure interaction in EGEA study
| Autor: | Anne Boland, Emmanuelle Bouzigon, Valérie Siroux, Marie-Hélène Dizier, Michel Guilloud-Bataille, Florence Demenais, Arnaud Lemainque, Mark Lathrop |
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| Přispěvatelé: | Génétique épidémiologique et structures des populations humaines (Inserm U535), Epidémiologie, sciences sociales, santé publique (IFR 69), Université Paris 1 Panthéon-Sorbonne (UP1)-Université Paris-Sud - Paris 11 (UP11)-École des hautes études en sciences sociales (EHESS)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Paris 1 Panthéon-Sorbonne (UP1)-Université Paris-Sud - Paris 11 (UP11)-École des hautes études en sciences sociales (EHESS)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM), Méthodologie statistique et épidémiologie génétique de maladies multifactorielles, Université d'Évry-Val-d'Essonne (UEVE)-Institut National de la Santé et de la Recherche Médicale (INSERM), Groupe de Recherche Sur Le Cancer du Poumon : Bases Moléculaires de la Progression Tumorale, Dépistage et Thérapie Génique, Institut Albert Bonniot-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre National de Génotypage (CNG), Commissariat à l'énergie atomique et aux énergies alternatives (CEA), FP6-FOOD-CT-2004-506378, FP6-LSH-2004-5-018996, ANR 05-SEST-020-02/05-9-97, INSERM, the European GA2LEN Network of Excellence, European GABRIEL grant and Agence Nationale pour la Recherche grant |
| Jazyk: | angličtina |
| Rok vydání: | 2007 |
| Předmět: |
Adult
Male Adolescent interaction Biology Identity by descent Genetic determinism 03 medical and health sciences 0302 clinical medicine Gene mapping Gene interaction genetic linkage Genetic linkage passive smoking exposure Genetics Genetic predisposition medicine Humans Genetic Predisposition to Disease Child Genetics (clinical) 030304 developmental biology Asthma Linkage (software) 0303 health sciences [SDV.GEN]Life Sciences [q-bio]/Genetics Genome Human fungi bronchial hyper-responsiveness asthma medicine.disease 3. Good health 030228 respiratory system Chromosomes Human Pair 1 Chromosomes Human Pair 5 Female Tobacco Smoke Pollution Bronchial Hyperreactivity Chromosomes Human Pair 4 Chromosomes Human Pair 17 Microsatellite Repeats |
| Zdroj: | European Journal of Human Genetics European Journal of Human Genetics, 2007, 15 (7), pp.810-815. ⟨10.1038/sj.ejhg.5201830⟩ European Journal of Human Genetics, Nature Publishing Group, 2007, 15 (7), pp.810-815. ⟨10.1038/sj.ejhg.5201830⟩ |
| ISSN: | 1018-4813 1476-5438 |
| DOI: | 10.1038/sj.ejhg.5201830⟩ |
| Popis: | Asthma and bronchial hyper-responsiveness (BHR), an asthma-related phenotype, result from many genetic (G) and environmental (E) factors. Passive exposure to tobacco smoke (ETS) in early life is one of these risk factors. Following a genome scan for asthma and associated phenotypes conducted in 295 French Epidemiological study on the Genetics and Environment of Asthma, our present aim was to investigate interactions between genetic susceptibility to asthma and to BHR with passive ETS using two different methods: the predivided sample test (PST) and the mean interaction test (MIT). PST and MIT consider the identical by descent (identity by descent) distribution at all markers in affected sib-pairs with 2, 1 or 0 sib(s) exposed to ETS. While the PST allows detection of both linkage and G x E interaction, the MIT tests for linkage by taking into account a possible interaction. Among the six regions detected at P |
| Databáze: | OpenAIRE |
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