FDG-PET in carcinoma of the uterine cervix with endometrial extension
| Autor: | Andrew J. Hope, Perry W. Grigsby, B S Paban Saha |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
Cancer Research
medicine.medical_specialty Pathology medicine.medical_treatment Population Urology Uterine Cervical Neoplasms Cervix Uteri Adenocarcinoma Disease-Free Survival Dilation and curettage Carcinoma Adenosquamous Fluorodeoxyglucose F18 medicine Carcinoma Humans Neoplasm Invasiveness Prospective Studies education Lymph node Cervical cancer education.field_of_study business.industry Cancer medicine.disease Combined Modality Therapy Supraclavicular lymph nodes Carcinoma Neuroendocrine Endometrial Neoplasms medicine.anatomical_structure Treatment Outcome Oncology Lymphatic Metastasis Positron-Emission Tomography Carcinoma Squamous Cell Female Radiopharmaceuticals business |
| Zdroj: | Cancer. 106(1) |
| ISSN: | 0008-543X |
| Popis: | BACKGROUND The authors wished to determine whether pretreatment pathologic evidence of endometrial invasion correlated with fluorine-18 fluorodeoxyglucose positron emission tomography (FDG-PET) findings and outcomes in patients with carcinoma of the uterine cervix. METHODS Pretreatment whole body FDG-PET was performed in 58 patients with cervical carcinoma who also underwent pathologic evaluation of the endometrium by biopsy or dilation and curettage. FDG-PET lymph node status, disease free survival, and overall survival were evaluated. RESULTS Thirty seven (64%) patients had pathologic evidence of endometrial invasion. Pelvic lymph node metastases were three times more frequent in patients with evidence of endometrial invasion compared with those without endometrial invasion (70% vs. 23%, P < 0.001). Patients with endometrial invasion also had a significantly increased risk of paraaortic and supraclavicular lymph node metastases at presentation (30% vs. 0% P = 0.006). Endometrial invasion was associated with a decreased 2-year disease-free survival (78% vs. 58%, P = 0.046) and overall survival (92% vs. 65%, P =0.047). CONCLUSIONS Endometrial extension in cervical cancer correlated strongly with risk of FDG-PET detected lymph node metastases in this study's population and was associated with a poor prognosis. Cancer 2006. © 2005 American Cancer Society. |
| Databáze: | OpenAIRE |
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