The BOADICEA model of genetic susceptibility to breast and ovarian cancers

Autor: A C, Antoniou, A P, Cunningham, J, Peto, D G, Evans, F, Lalloo, S A, Narod, H A, Risch, J E, Eyfjord, J L, Hopper, M C, Southey, H, Olsson, O, Johannsson, A, Borg, B, Pasini, B, Passini, P, Radice, S, Manoukian, D M, Eccles, N, Tang, E, Olah, H, Anton-Culver, E, Warner, J, Lubinski, J, Gronwald, B, Gorski, L, Tryggvadottir, K, Syrjakoski, O-P, Kallioniemi, H, Eerola, H, Nevanlinna, P D P, Pharoah, D F, Easton
Jazyk: angličtina
Rok vydání: 2008
Předmět:
Oncology
Cancer Research
cancer risk model
Genes
BRCA2
Genes
BRCA1
0302 clinical medicine
Family history
skin and connective tissue diseases
Ovarian Neoplasms
0303 health sciences
education.field_of_study
medicine.diagnostic_test
Genetic Carrier Screening
Age Factors
Neoplasms
Second Primary
Middle Aged
Corrigenda
3. Good health
030220 oncology & carcinogenesis
Female
Breast disease
Adult
medicine.medical_specialty
Population
Breast Neoplasms
genetic testing
03 medical and health sciences
Breast cancer
SDG 3 - Good Health and Well-being
Internal medicine
Genetic predisposition
medicine
Humans
Genetic Predisposition to Disease
Risk factor
education
Aged
030304 developmental biology
Genetic testing
Gynecology
Models
Genetic
business.industry
Cancer
Genetics and Genomics
BRCA1
medicine.disease
BRCA2
Mutation
Ovarian cancer
business
Zdroj: Antoniou, AC; Cunningham, AP; Peto, J; Evans, DG; Lalloo, F; Narod, SA; et al.(2008). The BOADICEA model of genetic susceptibility to breast and ovarian cancers: Updates and extensions. British Journal of Cancer, 98(8), 1457-1466. doi: 10.1038/sj.bjc.6604305. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/8tc5d3q2
British Journal of Cancer
Europe PubMed Central
Antoniou, A C, Cunningham, A P, Peto, J, Evans, D G, Lalloo, F, Narod, S A, Risch, H A, Eyfjord, J E, Hopper, J L, Southey, M C, Olsson, H, Johannsson, O, Borg, A, Pasini, B, Radice, P, Manoukian, S, Eccles, D M, Tang, N, Olah, E, Anton-Culver, H, Warner, E, Lubinski, J, Gronwald, J, Gorski, B, Tryggvadottir, L, Syrjakoski, K, Kallioniemi, O P, Eerola, H, Nevanlinna, H, Pharoah, P D P & Easton, D F 2008, ' The BOADICEA model of genetic susceptibility to breast and ovarian cancers : Updates and extensions ', British Journal of Cancer, vol. 98, no. 12, pp. 1457-1466 . https://doi.org/10.1038/sj.bjc.6604411
ISSN: 1532-1827
0007-0920
DOI: 10.1038/sj.bjc.6604411
Popis: Multiple genetic loci confer susceptibility to breast and ovarian cancers. We have previously developed a model (BOADICEA) under which susceptibility to breast cancer is explained by mutations in BRCA1 and BRCA2, as well as by the joint multiplicative effects of many genes (polygenic component). We have now updated BOADICEA using additional family data from two UK population-based studies of breast cancer and family data from BRCA1 and BRCA2 carriers identified by 22 population-based studies of breast or ovarian cancer. The combined data set includes 2785 families (301 BRCA1 positive and 236 BRCA2 positive). Incidences were smoothed using locally weighted regression techniques to avoid large variations between adjacent intervals. A birth cohort effect on the cancer risks was implemented, whereby each individual was assumed to develop cancer according to calendar period-specific incidences. The fitted model predicts that the average breast cancer risks in carriers increase in more recent birth cohorts. For example, the average cumulative breast cancer risk to age 70 years among BRCA1 carriers is 50% for women born in 1920-1929 and 58% among women born after 1950. The model was further extended to take into account the risks of male breast, prostate and pancreatic cancer, and to allow for the risk of multiple cancers. BOADICEA can be used to predict carrier probabilities and cancer risks to individuals with any family history, and has been implemented in a user-friendly Web-based program (http://www.srl.cam.ac.uk/ genepi/boadicea/boadicea_home.html). © 2008 Cancer Research UK.
Databáze: OpenAIRE
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