| Autor: |
Kohei Shiroshita, Ryohei Abe, Shintaro Watanuki, Shinya Fujita, Hitomi Nakayama, Masatoshi Sakurai, Jun Kato, Rie Yamazaki, Chieko Sumiya, Yuya Koda, Takehiko Mori, Kentaro Yamaguchi, Shinichiro Okamoto |
| Rok vydání: |
2020 |
| Předmět: |
|
| Zdroj: |
J Infect Dis |
| ISSN: |
1537-6613 |
| Popis: |
Nontuberculous mycobacteria (NTM) infect children with increasing frequency worldwide. Using blood and lymph node tissue from children with NTM lymphadenitis, and uninfected lymph node tissue from community controls, we evaluated helper T (T(H)) cells in functional assays of T(H)1/T(H)17 differentiation and measured the concentration of their associated cytokines at the site of infection. Circulating T(H) cells from infected children were attenuated in their T(H)1/T(H)17 differentiation capacity and expressed less interferon γ and interleukin 17 after polyclonal stimulation. Similar differences were observed at the site of infection, where most cytokine concentrations were unchanged relative to controls. Our data are consistent with a model wherein T(H)1/T(H)17 differentiation is attenuated in NTM-infected children. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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