Hemodynamic and metabolic effects of a new pediatric dobutamine formulation in hypoxic newborn pigs
| Autor: | Adolf Valls-i-Soler, Heike Rabe, Carmen Rey-Santano, Juan M Lopez-de-Heredia, Victoria E. Mielgo |
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| Rok vydání: | 2016 |
| Předmět: |
Male
Cardiotonic Agents Sus scrofa Cardiac index Hemodynamics Blood Pressure 030204 cardiovascular system & hematology 03 medical and health sciences 0302 clinical medicine Oxygen Consumption Superior vena cava Heart Rate 030225 pediatrics Dobutamine medicine Animals Hypoxia Spectroscopy Near-Infrared business.industry Stroke Volume Hypoxia (medical) 3. Good health Peripheral Oxygen RJ0251 Blood pressure medicine.anatomical_structure Animals Newborn Anesthesia Pediatrics Perinatology and Child Health Vascular resistance Female Vascular Resistance medicine.symptom business medicine.drug |
| Zdroj: | Pediatric research. 81(3) |
| ISSN: | 1530-0447 0031-3998 |
| Popis: | Background: The aim of our study was to measure drug-related changes in hemodynamics and oxygen metabolism in response to different doses of an age-appropriate dobutamine formulation in hypoxic pigs. A secondary aim was to validate superior vena cava flow (SVCF) as a marker of cardiac index (CI) for subsequent clinical trials of this formulation in humans.\ud \ud Methods: Newborn pigs (n=18) were exposed to 2h-hypoxia (10-15% oxygen) followed by reoxygenation (21-30% oxygen 4h). After 1h-reoxygenation, pigs were randomized to: control group (no treatment), dobutamine infusion at a rate of 10-15μg/kg/min or 15-20μg/kg/min. Dobutamine groups received two dobutamine doses during 30min with a 60min washout period between doses. Cardiovascular profile and oxygen metabolism were monitored. In four animals an ultrasonic perivascular flow probe was placed around superior vena cava to measure SVCF.\ud \ud Results: Hypoxia significantly decreased CI, systemic-vascular-resistance and mean-arterial-bloodpressure (MABP). Dobutamine doses significantly increased heart-rate, CI and oxygen-delivery without changes in stroke-volume and MABP. Only 10-15μg/kg/min increased oxygen consumption and peripheral tissue oxygenation measured by Near-infrared-spectroscopy. A positive correlation was observed between SVCF and CI.\ud \ud Conclusion: The new pediatric dobutamine formulation improved hemodynamic status, with dose-specific\ud differences in metabolic response. SVCF may be a useful surrogate for CI in subsequent clinical trials. |
| Databáze: | OpenAIRE |
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