Cellular immunity in myasthenia gravis after thymectomy and corticosteroid therapy
| Autor: | Hiroyuki Kamei, Hiroko Yamasaki, Hidehiko Shimura, Sachiko Kawanami, Makoto Okumura, Takayasu Shirakusa, Jiro Oita, Shoichiro Mori |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
Adult
Male medicine.medical_specialty Cellular immunity Adolescent Lymphocyte medicine.medical_treatment CD3 Adrenal Cortex Hormones Internal medicine Myasthenia Gravis medicine Humans Sensitization Acetylcholine receptor Aged Immunity Cellular biology business.industry General Medicine Middle Aged medicine.disease Thymectomy Combined Modality Therapy Myasthenia gravis Lymphocyte Subsets medicine.anatomical_structure Endocrinology Cell Migration Inhibition biology.protein Female business CD8 |
| Zdroj: | Japanese journal of medicine. 29(2) |
| ISSN: | 0021-5120 |
| Popis: | Clinical and immunological changes in patients with myasthenia gravis (MG) who had extended thymectomy (Tx) and/or corticosteroid therapy were examined to elucidate the mechanisms of improvement following the treatments. The changes found were: 1) After Tx and steroid therapy, in patients with MG who showed clinical improvement, the CD4/CD8 ratio and B lymphocyte subpopulations were markedly decreased. 2) Linear correlations between two T-cell subsets were evident in CD3 against CD4 and CD4/CD8 against CD4 after both Tx and steroid therapy. 3) T lymphocytes-CD8 decreased immediately after Tx and returned to pre-treatment levels within three weeks. 4) Cellular sensitization against a nicotine acetylcholine receptor (AChR)-like protein isolated from fetal calf thymus decreased after steroid therapy. These results indicate that clinical improvement in MG after the treatments was accompanied by a decrease in helper/inducer T lymphocytes, B lymphocytes and specific lymphocyte sensitization against nicotinic AChR. |
| Databáze: | OpenAIRE |
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