The effects of resveratrol on the expression of VEGF, TGF-β, and MMP-9 in endometrial stromal cells of women with endometriosis
| Autor: | Naheed Aryaeian, Zahra Moradi, Nesa Rashidi, Sepideh Khodaverdi, Ali-Akbar Delbandi, Tahereh Arablou, Roya Kolahdouz-Mohammadi |
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| Rok vydání: | 2021 |
| Předmět: |
Adult
Vascular Endothelial Growth Factor A Stromal cell Reproductive disorders Science Endometriosis Matrix metalloproteinase Resveratrol Article Andrology 03 medical and health sciences Basal (phylogenetics) chemistry.chemical_compound 0302 clinical medicine Transforming Growth Factor beta Gene expression Humans Medicine Immunological disorders Cells Cultured Nutrition 030219 obstetrics & reproductive medicine Multidisciplinary Dose-Response Relationship Drug business.industry Middle Aged medicine.disease Vascular endothelial growth factor Gene Expression Regulation Matrix Metalloproteinase 9 chemistry 030220 oncology & carcinogenesis Cytokines Female Stromal Cells business Transforming growth factor |
| Zdroj: | Scientific Reports Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021) |
| ISSN: | 2045-2322 |
| Popis: | Resveratrol is a phytochemical with anti-angiogenic, anti-inflammatory, and antioxidant properties. The present study has evaluated the effect of resveratrol on the expression of vascular endothelial growth factor (VEGF), transforming growth factor-β (TGF-β) and matrix metalloproteinase-9 (MMP-9) as factors related to endometriosis progression. Thirteen eutopic (EuESCs) and 8 ectopic (EESCs) endometrial stromal cells from women with endometriosis and 11 control endometrial stromal cells (CESCs) were treated with resveratrol (100 µM) for 6, 24 and 48 h. The gene and protein expression levels of VEGF, TGF-β, and MMP-9 were measured using real-time PCR and ELISA methods, respectively. Results showed that the basal gene and protein expression of VEGF and MMP-9 were higher in EESCs compared to EuESCs and CESCs (P VEGF gene expression was statistically more noticeable in EESCs compared to EuESCs and CESCs (P |
| Databáze: | OpenAIRE |
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