Association between intestinal lymphangiectasia and expression of inducible nitric oxide synthase in dogs with lymphoplasmacytic enteritis

Autor: Itsuma Nagao, T. Nakagawa, Masaya Tsuboi, Koichi Ohno, Yuko Goto-Koshino, Hajime Tsujimoto, Hirotaka Tomiyasu, Takuro Nagahara, Kazuyuki Uchida, James K. Chambers
Rok vydání: 2022
Předmět:
Zdroj: Journal of Veterinary Medical Science. 84:20-24
ISSN: 1347-7439
0916-7250
DOI: 10.1292/jvms.21-0363
Popis: Intestinal lymphangiectasia (IL) is a common complication in dogs. Since nitric oxide (NO) is known to relax the lymphatic vessel, we evaluated inducible NO synthase (iNOS) expression using immunohistochemistry in 13 dogs with lymphoplasmacytic enteritis (LPE) with or without IL. The duodenal iNOS expressing cells were significantly increased in dogs with IL-negative or IL-positive LPE dogs (P=0.025, P=0.007) compared with control dogs. However, there was no significant difference in iNOS expression between IL-positive and IL-negative tissues. Based on these results, there is no clear evidence for the NO overproduction in the pathogenesis of IL in dogs with LPE. Factors other than NO could, thus, contribute to IL in dogs with LPE.
Databáze: OpenAIRE