Association between intestinal lymphangiectasia and expression of inducible nitric oxide synthase in dogs with lymphoplasmacytic enteritis
Autor: | Itsuma Nagao, T. Nakagawa, Masaya Tsuboi, Koichi Ohno, Yuko Goto-Koshino, Hajime Tsujimoto, Hirotaka Tomiyasu, Takuro Nagahara, Kazuyuki Uchida, James K. Chambers |
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Rok vydání: | 2022 |
Předmět: |
Pathology
medicine.medical_specialty Duodenum Nitric Oxide Synthase Type II Nitric Oxide Nitric oxide Enteritis Pathogenesis chemistry.chemical_compound Dogs Animals Medicine Dog Diseases General Veterinary biology business.industry Lymph duct medicine.disease Immunohistochemistry Nitric oxide synthase chemistry Intestinal lymphangiectasia biology.protein business Complication |
Zdroj: | Journal of Veterinary Medical Science. 84:20-24 |
ISSN: | 1347-7439 0916-7250 |
DOI: | 10.1292/jvms.21-0363 |
Popis: | Intestinal lymphangiectasia (IL) is a common complication in dogs. Since nitric oxide (NO) is known to relax the lymphatic vessel, we evaluated inducible NO synthase (iNOS) expression using immunohistochemistry in 13 dogs with lymphoplasmacytic enteritis (LPE) with or without IL. The duodenal iNOS expressing cells were significantly increased in dogs with IL-negative or IL-positive LPE dogs (P=0.025, P=0.007) compared with control dogs. However, there was no significant difference in iNOS expression between IL-positive and IL-negative tissues. Based on these results, there is no clear evidence for the NO overproduction in the pathogenesis of IL in dogs with LPE. Factors other than NO could, thus, contribute to IL in dogs with LPE. |
Databáze: | OpenAIRE |
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