Quantifying changes in innate immune function following liver transplantation for chronic liver disease
| Autor: | Martin Schindl, M. Bodingbauer, Benjamin M. Stutchfield, Stephen J. Wigmore, Anya Adair, Sonia J. Wakelin, Stuart J. Forbes |
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| Rok vydání: | 2019 |
| Předmět: |
Male
medicine.medical_specialty Cirrhosis medicine.medical_treatment Liver transplantation Chronic liver disease Gastroenterology Extracorporeal End Stage Liver Disease Sepsis 03 medical and health sciences 0302 clinical medicine Immunity Internal medicine Living Donors medicine Humans Postoperative Period Radionuclide Imaging Liver support systems Innate immune system Hepatology business.industry Middle Aged medicine.disease Immunity Innate Transplant Recipients Liver Transplantation Liver 030220 oncology & carcinogenesis Female 030211 gastroenterology & hepatology business |
| Zdroj: | HPB. 21:1322-1326 |
| ISSN: | 1365-182X |
| DOI: | 10.1016/j.hpb.2019.02.004 |
| Popis: | BACKGROUND Liver transplantation (LT) offers patients with cirrhosis long-term survival, however many die from sepsis whilst awaiting LT. The liver's role in innate immunity may be key to improving outcomes, but the immune effects of LT have not been quantified. METHODS Innate immune capacity was assessed by clearance of 99mTc-Albumin nanospheres in patients with chronic liver failure before and after LT. RESULTS Twenty-eight patients with chronic liver disease on the LT waiting list entered the study during the twelve-month study period and nine patients underwent LT and completed the study protocol. One patient developed hepatic artery thrombosis in |
| Databáze: | OpenAIRE |
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