Urine Levels of Phthalate Metabolites and Bisphenol A in Relation to Main Metabolic Syndrome Components: Dyslipidemia, Hypertension and Type 2 Diabetes. A pilot study
| Autor: | Martin Haluzik, Milos Mraz, Jana Pavloušková, Štěpán Svačina, Roman Piecha, Martin Matoulek, Dagmar Matějková, Marek Malý, Karel Vrbík, Z Lacinová, Adam Vavrouš, Dana Müllerová |
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| Rok vydání: | 2016 |
| Předmět: |
Male
medicine.medical_specialty Phthalic Acids Pilot Projects 030209 endocrinology & metabolism Type 2 diabetes Urine 010501 environmental sciences 01 natural sciences 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Phenols Internal medicine Diabetes mellitus medicine Humans Outpatient clinic Benzhydryl Compounds Chromatography High Pressure Liquid Czech Republic Dyslipidemias 0105 earth and related environmental sciences Metabolic Syndrome business.industry Public Health Environmental and Occupational Health Phthalate General Medicine Middle Aged medicine.disease Obesity Endocrinology Diabetes Mellitus Type 2 chemistry Hypertension Female Metabolic syndrome business Biomarkers Dyslipidemia |
| Zdroj: | Central European Journal of Public Health. 24:297-301 |
| ISSN: | 1803-1048 1210-7778 |
| DOI: | 10.21101/cejph.a4704 |
| Popis: | Aim: Human exposure to organic pollutants (some of them also called endocrine disruptors) can be associated with adverse metabolic health outcomes including type 2 diabetes. The aim of this study was to compare the urine levels of bisphenol A and phthalate metabolites in subgroups of patients with metabolic syndrome composed of patients with and without three important components of metabolic syndrome (hypertension, dyslipidemia and diabetes). Methods: We have investigated 24 hours urine samples of 168 patients with metabolic syndrome from the Metabolic Outpatient Department of General University Hospital in Prague. Using standard metabolic syndrome criteria, we classified patients as dyslipidemic (n=87), hypertensive (n=96), and type 2 diabetic (n=58). Bisphenol A and 15 metabolites of phthalates were evaluated in relation to creatinine excretion. Samples were analysed with enzymatic cleavage of glucuronide using ultra-high-performance liquid chromatography-electrospray ionization tandem mass spectrometry in one laboratory with external quality control. Results: Four metabolites, mono-n-butyl phthalate, mono-(2-ethyl-5-hydroxyhexyl) phthalate, mono-(2-ethyl-5-oxohexyl) phthalate, and mono-(2-ethyl-5-carboxypentyl) phthalate showed significantly higher levels in diabetic compared to non-diabetic patients (p |
| Databáze: | OpenAIRE |
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