Rhegmatogenous retinal detachment following intravitreal ocriplasmin
| Autor: | Diana Depla, David H. W. Steel, Richard Haynes, Mahi M. K. Muqit, N Price, Haifa A. Madi, Morten la Cour, Niall Patton, Sarit Y. Lesnik-Oberstein |
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| Přispěvatelé: | Ophthalmology |
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Male
Visual acuity genetic structures Visual Acuity Retinal perforation Pharmacological vitreolysis Vitreomacular traction Vitreous Detachment Retinal tears chemistry.chemical_compound 0302 clinical medicine 030212 general & internal medicine Fibrinolysin Macular hole Retinal detachment Middle Aged Prognosis Sensory Systems Retinal Tear Intravitreal Injections Retinal Disorders Female medicine.symptom Tomography Optical Coherence medicine.medical_specialty Retina 03 medical and health sciences Cellular and Molecular Neuroscience Ophthalmology medicine Humans Aged Retrospective Studies business.industry Ocriplasmin Retinal Detachment medicine.disease Retinal Perforations Peptide Fragments eye diseases Surgery chemistry 030221 ophthalmology & optometry business Follow-Up Studies |
| Zdroj: | Graefe s archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 254(12), 2333-2338. Springer Verlag Graefe's Archive for Clinical and Experimental Ophthalmology |
| ISSN: | 0721-832X |
| Popis: | Purpose To describe the characteristics and outcomes of patients presenting with rhegmatogenous retinal detachment (RRD) after ocriplasmin (OCP) injection. Methods Retrospective, multi-centre, observational case series with case note review. Results Eight patients with symptomatic vitreomacular traction (six with concomitant macular hole) were diagnosed with RRD after a median of 16 days (range 3–131 days) post-OCP injection. Presentation was within 3 weeks of the OCP injection in six of the cases. Five patients presented with symptoms post-OCP, and three were diagnosed asymptomatically on planned visits. Seven cases were phakic, one had high myopia (>8 dioptres), and two cases had lattice degeneration. Following RRD surgery, hole closure was achieved in 5/6 MH cases. The final median BCVA at 7 months was 20/80 (range 20/40–20/1200) similar to the baseline BCVA 20/80, with four patients gaining ≥1 line of vision compared to baseline but three losing ≥3 lines. Conclusions RRD is a non-negligible risk associated with intravitreal OCP, and it should be used with caution in eyes with high myopia and peripheral retinal pathology predisposing to RRD. Detailed peripheral retinal examination is recommended pre- and postoperatively at all visits. Patients should be advised to seek attention if symptoms recur after initial presentation. |
| Databáze: | OpenAIRE |
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