Villitis of Unknown Etiology in the Placenta of a Pregnancy Complicated by COVID-19
| Autor: | Resmiye Irmak Yuzuguldu, Mustafa Cuneyt Cevizci, Erdener Özer, Erkan Cagliyan, Nuray Duman |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Adult
placenta Physiology Inflammation 02 engineering and technology 030204 cardiovascular system & hematology Pathology and Forensic Medicine 03 medical and health sciences 020210 optoelectronics & photonics 0302 clinical medicine Immune system Pregnancy Placenta Chronic Villitis Pathology 0202 electrical engineering electronic engineering information engineering medicine RB1-214 Humans Pregnancy Complications Infectious Fetus SARS-CoV-2 business.industry Infant Newborn COVID-19 medicine.disease Immunohistochemistry medicine.anatomical_structure Gestation Female Chorionic Villi medicine.symptom business Villitis of unknown etiology villitis of unknown etiology |
| Zdroj: | Türk Patoloji Dergisi, Vol 37, Iss 2, Pp 167-171 (2021) |
| Popis: | Villitis of unknown etiology (VUE) is noninfectious chronic villitis thought to be associated with fetal growth restriction and stillbirth. COVID-19 and the pandemic SARS-CoV-2 infection can cause an increased risk in pregnant women for potential maternal and fetal complications from an immunological mechanism. We report a 39-week-gestational-age infant delivered to a 37-year-old mother diagnosed with SARS-CoV-2 infection at 37 weeks gestation. The placental examination showed the morphological features of VUE. We showed immunohistochemically that macrophages and CD4-positive T cells predominated in the villous tissue, although elevated numbers of CD8-positive cells were also present. We hypothesize that VUE may represent a maternal anti-viral immune response, in this case to SARS-CoV-2. |
| Databáze: | OpenAIRE |
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