DNA methylation and body mass index from birth to adolescence : meta-analyses of epigenome-wide association studies

Autor: Anni Heiskala, Gwen Tindula, Samuli Tuominen, Anne P. Starling, Vincent W. V. Jaddoe, Samantha Lent, Katri Räikkönen, Carlos Ruiz-Arenas, Thorkild I. A. Sørensen, Dariusz Gruszfeld, Cathrine Hoyo, Johanna Lepeule, Tong Gong, Erik Melén, Ellen A. Nohr, Ivana V. Yang, John W. Holloway, Jari Lahti, Susan Ewart, Mariona Bustamante, Veit Grote, Marjo-Riitta Järvelin, Brenda Eskenazi, Philip E. Melton, Catarina Almqvist, Robert Karlsson, Elisabeth B. Binder, Weiming Zhang, Dereje D. Jima, Dana Dabelea, Maria C. Magnus, Lucas A. Salas, Jean-Paul Langhendries, Trevor A. Mori, Syed Hasan Arshad, Peter Rzehak, Florianne O L Vehmeijer, Leanne K. Küpers, Inger Kull, Caroline L Relton, Judith M. Vonk, Emily Oken, Vilhelmina Ullemar, Cancan Qi, Wilfried Karmaus, Martine Vrijheid, Darina Czamara, Peter L. Molloy, Anna Bergström, Olena Gruzieva, Hongmei Zhang, Wenche Nystad, Lu Gao, Marie-France Hivert, Beverly S. Muhlhausler, Rachel L. Maguire, Lawrence J. Beilin, Jason P. Ross, Eva Corpeleijn, Faisal I. Rezwan, Sylvain Sebert, Siri E. Håberg, Gemma C Sharp, Cheng-Jian Xu, Natalia Ferre, Gerard H. Koppelman, Leda Chatzi, Nina Holland, Janine F. Felix, Berthold Koletzko, Stephanie J. London, Christian M. Page, Harold Snieder, Carrie V. Breton, Susan K. Murphy, Rae-Chi Huang, Claire Monnereau, Elvira Verduci, Karen Huen, Geòrgia Escaramís, Gunn Marit Aasvang, Andrea A. Baccarelli, Paul Yousefi, Sarah E. Reese, Sheryl L. Rifas-Shiman
Přispěvatelé: Department of Psychology and Logopedics, Erasmus University Medical Center [Rotterdam] (Erasmus MC), University of Bristol [Bristol], University of Groningen [Groningen], Geisel School of Medicine at Dartmouth, Instituto de Salud Global - Institute For Global Health [Barcelona] (ISGlobal), Universitat Pompeu Fabra [Barcelona] (UPF), CIBER de Epidemiología y Salud Pública (CIBERESP), Boston University School of Medicine (BUSM), Boston University [Boston] (BU), North Carolina State University [Raleigh] (NC State), University of North Carolina System (UNC), University of California [Berkeley], University of California, National Institutes of Health [Bethesda] (NIH), University Medical Center Groningen [Groningen] (UMCG), Groningen Research Institute for Asthma and COPD (GRIAC), Karolinska Institutet [Stockholm], Centre for Occupational and Environmental Medicine [Stockholm, Sweden] (Region Stockholm), Norwegian Institute of Public Health [Oslo] (NIPH), Oslo University Hospital [Oslo], Cranfield University, University of Southampton, Curtin University [Perth], Planning and Transport Research Centre (PATREC), The University of Western Australia (UWA), University of South-Eastern Norway (USN), University of Southern Denmark (SDU), University of Barcelona, Universitat de Girona [Girona], Universitat de Girona (UdG), Dr von Hauner Children's Hospital [Munich, Germany], Ludwig-Maximilians-Universität München (LMU), University of Oulu, University of Helsinki, University of Southern California (USC), CSIRO - North Ryde Site [New SouthWales, Australia], Colorado School of Public Health [Aurora, CO, USA] (CSPH), University of Colorado Anschutz [Aurora], Max Planck Institute of Psychiatry, Max-Planck-Gesellschaft, Emory University School of Medicine, Emory University [Atlanta, GA], Keck School of Medicine [Los Angeles], Michigan State University [East Lansing], Michigan State University System, Universitat Rovira i Virgili, Children’s Memorial Health Institute [Warsaw, Poland] (CMHI), Sachs’ Children and Youth Hospital [Stockholm, Sweden], Clinique Saint-Vincent [Liège-Rocourt,Belgium] (Groupe santé CHC), Université Grenoble Alpes (UGA), Institute for Advanced Biosciences / Institut pour l'Avancée des Biosciences (Grenoble) (IAB), Centre Hospitalier Universitaire [Grenoble] (CHU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Etablissement français du sang - Auvergne-Rhône-Alpes (EFS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA), Duke University Medical Center, Harvard Medical School [Boston] (HMS), University of Milan, Helmholtz Centre for Infection Research (HZI), Centre for Experimental and Clinical Infection Research [Hanover] (TWINCORE), University of Colorado [Colorado Springs] (UCCS), Jewish General Hospital, University of Memphis (U of M), CSIRO ADELAIDE AUS, Partenaires IRSTEA, Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA), University of Turku, Karolinska University Hospital [Stockholm], Imperial College London, Brunel University London [Uxbridge], Oulu University Hospital [Oulu], University of Copenhagen = Københavns Universitet (KU), The David Hide Asthma and Allergy Research Centre [Southampton, UK], St Mary's Hospital-University Hospital Southampton NHS Foundation Trust, Beatrix Children's Hospital [Groningen, Pays-Bas], Massachusetts General Hospital [Boston], Université de Sherbrooke (UdeS), Mailman School of Public Health Columbia University [New-York], European Project: 733206,H2020,H2020-SC1-2016-RTD,LIFECYCLE(2017), Epidemiology, Pediatrics, Life Course Epidemiology (LCE), HZI,Helmholtz-Zentrum für Infektionsforschung GmbH, Inhoffenstr. 7,38124 Braunschweig, Germany., University of California [Berkeley] (UC Berkeley), University of California (UC), Helsingin yliopisto = Helsingfors universitet = University of Helsinki, Università degli Studi di Milano = University of Milan (UNIMI), University of Copenhagen = Københavns Universitet (UCPH), BARBAGALLO, Maïlys, Early-life stressors and LifeCycle health - LIFECYCLE - - H20202017-01-01 - 2021-12-31 - 733206 - VALID
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Male
0301 basic medicine
Pediatric Obesity
[SDV]Life Sciences [q-bio]
CHILDHOOD
LOCI
Physiology
CHILDREN
Cardiovascular
Oral and gastrointestinal
Epigenesis
Genetic
Epigenome
0302 clinical medicine
Pregnancy
2.1 Biological and endogenous factors
Medicine
PROMOTER METHYLATION
Childhood obesity
CORD BLOOD
Aetiology
Child
Genetics (clinical)
Body mass index
Cancer
Genetics & Heredity
Pediatric
2. Zero hunger
DNA methylation
1184 Genetics
developmental biology
physiology
Methylation
Fetal Blood
[SDV] Life Sciences [q-bio]
Stroke
Child
Preschool
030220 oncology & carcinogenesis
OBESITY
Molecular Medicine
Female
Epigenetics
ADIPOSITY
social and economic factors
Life Sciences & Biomedicine
Adolescent
Clinical Sciences
03 medical and health sciences
BMI
Genetic
2.3 Psychological
Genetics
Humans
LMS METHOD
Obesity
Preschool
Molecular Biology
Metabolic and endocrine
Nutrition
Genetic association
0604 Genetics
Science & Technology
business.industry
Research
Prevention
Human Genome
Parturition
1103 Clinical Sciences
medicine.disease
Cross-Sectional Studies
030104 developmental biology
[SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie
DISCOVERY
CpG Islands
[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie
business
Epigenesis
Zdroj: Genome Medicine
Genome Medicine, BioMed Central, 2020, 12 (1), pp.105. ⟨10.1186/s13073-020-00810-w⟩
Vehmeijer, F O L, Küpers, L K, Sharp, G C, Salas, L A, Lent, S, Jima, D D, Tindula, G, Reese, S, Qi, C, Gruzieva, O, Page, C, Rezwan, F I, Melton, P E, Nohr, E, Escaramís, G, Rzehak, P, Heiskala, A, Gong, T, Tuominen, S T, Gao, L, Ross, J P, Starling, A P, Holloway, J W, Yousefi, P, Aasvang, G M, Beilin, L J, Bergström, A, Binder, E, Chatzi, L, Corpeleijn, E, Czamara, D, Eskenazi, B, Ewart, S, Ferre, N, Grote, V, Gruszfeld, D, Håberg, S E, Hoyo, C, Huen, K, Karlsson, R, Kull, I, Langhendries, J P, Lepeule, J, Magnus, M C, Maguire, R L, Molloy, P L, Monnereau, C, Mori, T A, Oken, E, Räikkönen, K, Rifas-Shiman, S, Ruiz-Arenas, C, Sebert, S, Ullemar, V, Verduci, E, Vonk, J M, Xu, C J, Yang, I V, Zhang, H, Zhang, W, Karmaus, W, Dabelea, D, Muhlhausler, B S, Breton, C V, Lahti, J, Almqvist, C, Jarvelin, M R, Koletzko, B, Vrijheid, M, Sørensen, T I A, Huang, R C, Arshad, S H, Nystad, W, Melén, E, Koppelman, G H, London, S J, Holland, N, Bustamante, M, Murphy, S K, Hivert, M F, Baccarelli, A, Relton, C L, Snieder, H, Jaddoe, V W V & Felix, J F 2020, ' DNA methylation and body mass index from birth to adolescence : meta-analyses of epigenome-wide association studies ', Genome Medicine, vol. 12, no. 1, 105 . https://doi.org/10.1186/s13073-020-00810-w
Genome Medicine, 12(1):105. BioMed Central Ltd.
Genome medicine, vol 12, iss 1
Vehmeijer, F O L, Küpers, L K, Sharp, G C, Salas, L A, Lent, S, Jima, D D, Tindula, G, Reese, S, Qi, C, Gruzieva, O, Page, C, Rezwan, F I, Melton, P E, Nohr, E, Escaramís, G, Rzehak, P, Heiskala, A, Gong, T, Tuominen, S T, Gao, L, Ross, J P, Starling, A P, Holloway, J W, Yousefi, P, Aasvang, G M, Beilin, L J, Bergström, A, Binder, E, Chatzi, L, Corpeleijn, E, Czamara, D, Eskenazi, B, Ewart, S, Ferre, N, Grote, V, Gruszfeld, D, Håberg, S E, Hoyo, C, Huen, K, Karlsson, R, Kull, I, Langhendries, J P, Lepeule, J, Magnus, M C, Maguire, R L, Molloy, P L, Monnereau, C, Mori, T A, Oken, E, Räikkönen, K, Rifas-Shiman, S, Ruiz-Arenas, C, Sebert, S, Ullemar, V, Verduci, E, Vonk, J M, Xu, C J, Yang, I V, Zhang, H, Zhang, W, Karmaus, W, Dabelea, D, Muhlhausler, B S, Breton, C V, Lahti, J, Almqvist, C, Jarvelin, M R, Koletzko, B, Vrijheid, M, Sørensen, T I A, Huang, R C, Arshad, S H, Nystad, W, Melén, E, Koppelman, G H, London, S J, Holland, N, Bustamante, M, Murphy, S K, Hivert, M F, Baccarelli, A, Relton, C L, Snieder, H, Jaddoe, V W V & Felix, J F 2020, ' DNA methylation and body mass index from birth to adolescence : meta-analyses of epigenome-wide association studies ', Genome Medicine, vol. 12, 105 . https://doi.org/10.1186/s13073-020-00810-w
Genome medicine, 12(1):105. BMC
Genome medicine
United States
England
Genome Medicine, 2020, 12 (1), pp.105. ⟨10.1186/s13073-020-00810-w⟩
Vehmeijer, F O L, Küpers, L K, Sharp, G C, Salas, L A, Lent, S, Jima, D D, Tindula, G, Reese, S, Qi, C, Gruzieva, O, Page, C, Rezwan, F I, Melton, P E, Nohr, E, Escaramís, G, Rzehak, P, Heiskala, A, Gong, T, Tuominen, S T, Gao, L, Ross, J P, Starling, A P, Holloway, J W, Yousefi, P, Aasvang, G M, Beilin, L J, Bergström, A, Binder, E, Chatzi, L, Corpeleijn, E, Czamara, D, Eskenazi, B, Ewart, S, Ferre, N, Grote, V, Gruszfeld, D, Håberg, S E, Hoyo, C, Huen, K, Karlsson, R, Kull, I, Langhendries, J-P, Lepeule, J, Magnus, M C, Maguire, R L, Molloy, P L, Monnereau, C, Mori, T A, Oken, E, Räikkönen, K, Rifas-Shiman, S, Ruiz-Arenas, C, Sebert, S, Ullemar, V, Verduci, E, Vonk, J M, Xu, C-J, Yang, I V, Zhang, H, Zhang, W, Karmaus, W, Dabelea, D, Muhlhausler, B S, Breton, C V, Lahti, J, Almqvist, C, Jarvelin, M-R, Koletzko, B, Vrijheid, M, Sørensen, T I A, Huang, R-C, Arshad, S H, Nystad, W, Melén, E, Koppelman, G H, London, S J, Holland, N, Bustamante, M, Murphy, S K, Hivert, M-F, Baccarelli, A, Relton, C L, Snieder, H, Jaddoe, V W V & Felix, J F 2020, ' DNA methylation and body mass index from birth to adolescence : meta-analyses of epigenome-wide association studies ', Genome Medicine, vol. 12, no. 1, 105 (2020) . https://doi.org/10.1186/s13073-020-00810-w
ISSN: 1756-994X
Popis: Background DNA methylation has been shown to be associated with adiposity in adulthood. However, whether similar DNA methylation patterns are associated with childhood and adolescent body mass index (BMI) is largely unknown. More insight into this relationship at younger ages may have implications for future prevention of obesity and its related traits. Methods We examined whether DNA methylation in cord blood and whole blood in childhood and adolescence was associated with BMI in the age range from 2 to 18 years using both cross-sectional and longitudinal models. We performed meta-analyses of epigenome-wide association studies including up to 4133 children from 23 studies. We examined the overlap of findings reported in previous studies in children and adults with those in our analyses and calculated enrichment. Results DNA methylation at three CpGs (cg05937453, cg25212453, and cg10040131), each in a different age range, was associated with BMI at Bonferroni significance, P −7, with a 0.96 standard deviation score (SDS) (standard error (SE) 0.17), 0.32 SDS (SE 0.06), and 0.32 BMI SDS (SE 0.06) higher BMI per 10% increase in methylation, respectively. DNA methylation at nine additional CpGs in the cross-sectional childhood model was associated with BMI at false discovery rate significance. The strength of the associations of DNA methylation at the 187 CpGs previously identified to be associated with adult BMI, increased with advancing age across childhood and adolescence in our analyses. In addition, correlation coefficients between effect estimates for those CpGs in adults and in children and adolescents also increased. Among the top findings for each age range, we observed increasing enrichment for the CpGs that were previously identified in adults (birth Penrichment = 1; childhood Penrichment = 2.00 × 10−4; adolescence Penrichment = 2.10 × 10−7). Conclusions There were only minimal associations of DNA methylation with childhood and adolescent BMI. With the advancing age of the participants across childhood and adolescence, we observed increasing overlap with altered DNA methylation loci reported in association with adult BMI. These findings may be compatible with the hypothesis that DNA methylation differences are mostly a consequence rather than a cause of obesity.
Databáze: OpenAIRE
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