Instructions for Assembling the Early Mammalian Embryo
| Autor: | Stephanie Bissiere, Nicolas Plachta, Melanie D. White, Jennifer Zenker |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Cell Polarity Embryonic Development Cell Differentiation Embryo Cell Biology Computational biology Biology Cell fate determination Embryo Mammalian Biological noise Models Biological General Biochemistry Genetics and Molecular Biology Mice 03 medical and health sciences Blastocyst Imaging Three-Dimensional 030104 developmental biology Live cell imaging Morphogenesis Animals Cell Lineage Molecular Biology Function (biology) Developmental Biology |
| Zdroj: | Developmental Cell. 45:667-679 |
| ISSN: | 1534-5807 |
| DOI: | 10.1016/j.devcel.2018.05.013 |
| Popis: | The preimplantation mouse embryo is a simple self-contained system, making it an excellent model to discover how mammalian cells function in real time and in vivo. Work over the last decade has revealed some key morphogenetic mechanisms that drive early development, yielding rudimentary instructions for the generation of a mammalian embryo. Here, we review the instructions revealed thus far, and then discuss remaining challenges to discover upstream factors controlling cell fate determination, test the role of mechanisms based on biological noise, and take advantage of recent technological developments to advance the spatial and temporal resolution of our current understanding. |
| Databáze: | OpenAIRE |
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