Altered directed connectivity during processing of predictive stimuli in psychiatric patient populations
| Autor: | Pablo Diaz-Brage, Noa Fogelson |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Adult
Male medicine.medical_specialty Autism Spectrum Disorder Electroencephalography Young Adult Physiology (medical) Medicine Humans In patient Beta (finance) Psychiatry Depressive Disorder Major medicine.diagnostic_test business.industry Brain Middle Aged medicine.disease Control subjects Sensory Systems Neurology Autism spectrum disorder Schizophrenia Major depressive disorder Transfer entropy Female Neurology (clinical) Nerve Net business Photic Stimulation Psychomotor Performance Forecasting |
| Zdroj: | Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology. 132(11) |
| ISSN: | 1872-8952 |
| Popis: | Objectives The study investigated the role of top-down versus bottom-up connectivity, during the processing of predictive information, in three different psychiatric disorders. Methods Electroencephalography (EEG) was recorded during the performance of a task, which evaluates the ability to use predictive information in order to facilitate predictable versus random target detection. We evaluated EEG event-related directed connectivity, in patients with schizophrenia (SZ), major depressive disorder (MDD), and autism spectrum disorder (ASD), compared with healthy age-matched controls. Directed connectivity was evaluated using phase transfer entropy. Results We showed that top-down frontal-parietal connectivity was weaker in SZ (theta and beta bands) and ASD (alpha band) compared to control subjects, during the processing of stimuli consisting of the predictive sequence. In SZ patients, top-down connectivity was also attenuated, during the processing of predictive targets in the beta frequency band. In contrast, compared with controls, MDD patients displayed an increased top-down flow of information, during the processing of predicted targets (alpha band). Conclusions The findings suggest that top-down frontal-parietal connectivity is altered differentially across three major psychiatric disorders, specifically during the processing of predictive stimuli. Significance Altered top-down connectivity may contribute to the specific prediction deficits observed in each of the patient populations. |
| Databáze: | OpenAIRE |
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