Perinatal Antiretroviral Intensification to Prevent Intrapartum HIV Transmission When Antenatal Antiretroviral Therapy Is Initiated Less Than 8 Weeks Before Delivery
| Autor: | Patumrat Sripan, Saik Urien, Billy Amzal, Thitiporn Siriwachirachai, P. Kanjanavikai, Gonzague Jourdain, P. Sabsanong, Suporn Koetsawang, Tim R. Cressey, Sophie Le Coeur, Marc Lallemant, Tapnarong Jarupanich, Boonsong Rawangban, Virat Klinbuayaem, Nicole Ngo-Giang-Huong, Phpt site investigators, Phaiboon Wanasiri |
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| Přispěvatelé: | Drugs for Neglected Diseases Initiative, Certara, Institut de Recherche pour le Développement (IRD), Infections à Vih, Réservoirs, Pharmacologie des Antirétroviraux et Prévention de la Transmission Mère Enfant, Université Paris Descartes - Paris 5 (UPD5), Épidémiologie clinique, santé mère-enfant et VIH en Asie du Sud-Est (IRD_PHPT), Harvard University [Cambridge]-Chiang Mai University (CMU), Maladies infectieuses et vecteurs : écologie, génétique, évolution et contrôle (MIVEGEC), Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud]), Institut national d'études démographiques (INED) |
| Rok vydání: | 2020 |
| Předmět: |
prevention of mother-to-child transmission
HIV Infections 030312 virology [SHS]Humanities and Social Sciences MESH: Pregnancy Pregnancy Pharmacology (medical) Young adult MESH: Anti-HIV Agents MESH: Nevirapine Pregnancy Complications Infectious 0303 health sciences Transmission (medicine) Obstetrics MESH: Infant Newborn virus diseases MESH: Zidovudine clinical trial Lopinavir MESH: HIV Infections Viral Load Thailand historical control MESH: Mothers 3. Good health MESH: Infectious Disease Transmission Vertical Drug Combinations Infectious Diseases MESH: Young Adult Lamivudine Female MESH: Viral Load Viral load Zidovudine medicine.drug MESH: Lamivudine Adult medicine.medical_specialty Nevirapine Anti-HIV Agents MESH: Bayes Theorem antiretroviral therapy education Mothers Bayesian design Article 03 medical and health sciences Young Adult medicine Humans intrapartum transmission MESH: Pregnancy Complications Infectious MESH: Thailand MESH: Drug Combinations MESH: Humans business.industry Infant Newborn HIV MESH: Adult Bayes Theorem medicine.disease Infectious Disease Transmission Vertical meta-analysis Regimen business MESH: Female [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology |
| Zdroj: | J Acquir Immune Defic Syndr Journal of Acquired Immune Deficiency Syndromes Journal of Acquired Immune Deficiency Syndromes, Lippincott, Williams & Wilkins, 2020, 84 (3), pp.313-322. ⟨10.1097/QAI.0000000000002350⟩ Journal of Acquired Immune Deficiency Syndromes, Lippincott, Williams & Wilkins, 2020, ⟨10.1097/QAI.0000000000002350⟩ |
| ISSN: | 1944-7884 1525-4135 |
| Popis: | Introduction: Infants born to women living with HIV initiating combination antiretroviral therapy (cART) late in pregnancy are at high risk of intrapartum infection. Mother/infant perinatal antiretroviral intensification may substantially reduce this risk. Methods: In this single-arm Bayesian trial, pregnant women with HIV receiving standard of care antiretroviral prophylaxis in Thailand (maternal antenatal lopinavir-based cART; nonbreastfed infants 4 weeks' postnatal zidovudine) were offered "antiretroviral intensification" (labor single-dose nevirapine plus infant zidovudine-lamivudine-nevirapine for 2 weeks followed by zidovudine-lamivudine for 2 weeks) if their antenatal cART was initiated |
| Databáze: | OpenAIRE |
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