Low-Dose Oral Clonidine as Premedication before Intraocular Surgery in Retrobulbar Anesthesia
| Autor: | Klaus W. Ruprecht, Ralph-Thomas Kiefer, A. Rippa, Josef Weindler, Katja Wiech |
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| Rok vydání: | 2000 |
| Předmět: |
Male
Intraocular pressure genetic structures Premedication Sedation Conscious Sedation Administration Oral Hemodynamics Cataract Extraction Clonidine 03 medical and health sciences 0302 clinical medicine Double-Blind Method medicine Humans Prospective Studies Anesthetics Local Intraocular Pressure Aged Analgesics business.industry General Medicine Perioperative Ophthalmology Blood pressure Anesthesia 030221 ophthalmology & optometry Midazolam Female Test Anxiety Scale medicine.symptom business Orbit 030217 neurology & neurosurgery Anesthesia Local medicine.drug |
| Zdroj: | European Journal of Ophthalmology. 10:248-256 |
| ISSN: | 1724-6016 1120-6721 |
| Popis: | PURPOSE. We investigated whether low-dosed oral clonidine premedication before elective intraocular surgery in retrobulbar anesthesia is effective in terms of anxiolysis, sedation, stable hemodynamics, lower intraocular pressure and perioperative endocrine stress response. METHODS. In a prospective, randomised, double-blind study, 44 patients scheduled for elective intraocular surgery received either 0.15 mg clonidine (n=22) or a matched placebo (n=22) orally 60 minutes before retrobulbar anesthesia. The main study parameters were sedation, anxiolysis, hemodynamics and intraocular pressure. Additionally, mediators of endocrine stress responses were measured five times, in 13 patients after clonidine and 12 after placebo. RESULTS. After clonidine 86% of the patients showed sedation and after placebo 90.9% showed no sedation (p |
| Databáze: | OpenAIRE |
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