Current and future aggressive peripheral T-cell lymphoma treatment paradigms, biological features and therapeutic molecular targets
| Autor: | G. Perez-Manga, Antonio Gutierrez, B. Martínez-Delgado, J. Rodríguez |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Oncology
medicine.medical_specialty medicine.medical_treatment Salvage therapy Hematopoietic stem cell transplantation Targeted therapy Drug Delivery Systems Internal medicine Antineoplastic Combined Chemotherapy Protocols Biomarkers Tumor Medicine Humans Neoplasm Invasiveness Chromosome Aberrations Chemotherapy business.industry Gene Expression Profiling Lymphoma T-Cell Peripheral Hematology Immunotherapy Genomics medicine.disease Peripheral T-cell lymphoma Gene Expression Regulation Neoplastic Immunology Molecular targets Conventional chemotherapy business Stem Cell Transplantation |
| Zdroj: | Critical reviews in oncology/hematology. 71(3) |
| ISSN: | 1879-0461 |
| Popis: | Prognosis of PTCL is generally poor when treated with conventional chemotherapy regimens used in B-cell aggressive lymphomas. Recent advances in genomic and molecular profiling of PTCL have allowed to further insight this heterogeneous group of neoplasias and their main prognostic factors. This review will try to summarize the main clinical problems related to standard frontline and salvage therapy, including the use of conventional chemotherapy and high-dose, dose-dense and immunotherapeutic strategies, as well as new approaches based on biological knowledge and the use of new drugs or immunotherapy. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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