Morning attenuation of endothelium-dependent, flow-mediated dilation in healthy young men: Possible connection to morning peak of cardiac events?
| Autor: | Akira Kurita, Hirokuni Etsuda, Yoshihiro Matsushima, Koh Arakawa, Kimio Satomura, Kuhara R, Fumitaka Ohsuzu, Akimi Uehata, Akira Hamabe, Takasi Akima, Hiroyuki Kusano, Bonpei Takase |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
Adult
Male medicine.medical_specialty Brachial Artery Blood Pressure Endothelium dependent Heart Rate medicine.artery Internal medicine medicine Humans Circadian rhythm Brachial artery Reactive hyperemia Coronary atherosclerosis Ultrasonography Morning business.industry Diurnal temperature variation Articles General Medicine Circadian Rhythm Vasodilation Clinical research Endocrinology Cardiovascular Diseases Regional Blood Flow cardiovascular system Cardiology Vascular Resistance Endothelium Vascular Cardiology and Cardiovascular Medicine business circulatory and respiratory physiology |
| Zdroj: | Clinical Cardiology. 22:417-421 |
| ISSN: | 1932-8737 0160-9289 |
| DOI: | 10.1002/clc.4960220610 |
| Popis: | Background and hypothesis: Brachial artery flow-mediated dilation (FMD), a noninvasive, widely used clinical index of endothelial function and magnitude of FMD, has been reported to be closely related to many coronary risk factors and coronary atherosclerosis. However, there has been no study that examines the diurnal change of FMD. We designed this study to reveal the diurnal variation of FMD in healthy volunteers. Methods: We examined FMD in response to reactive hyperemia by high resolution ultrasound in 13 healthy young men (age 25–32) at four different times over the course of a day. Results: Mean measures of brachial artery FMD was 4.0% at 8:00, 5.3% at 12:00, 9.7% at 17:00, and 6.9% at 21:00 hours. Flow-mediated dilation at 8:00 and at 12:00 hours was significantly lower than that at 17:00 (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|