Survey of urinary nickel in peritoneal dialysis patients
| Autor: | Shu-Man Weng, Shang-Syuan Chen, I-Kwan Wang, Ching-Wei Hsu, Tzung-Hai Yen, Hsiao-Chen Ning, Ya-Ching Huang, Jang-Jih Lu, Cheng-Hao Weng, Chia-Ni Lin, Wen-Hung Huang, Tsu-Lan Wu |
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| Rok vydání: | 2017 |
| Předmět: |
Nephrology
inorganic chemicals medicine.medical_specialty medicine.medical_treatment Urinary system Urine Peritoneal dialysis Elevated serum 030207 dermatology & venereal diseases 03 medical and health sciences nickel 0302 clinical medicine Internal medicine medicine 030212 general & internal medicine inductively coupled plasma mass spectrometry high sensitivity C-reactive protein business.industry University hospital Inflammatory biomarkers Surgery Oncology peritoneal dialysis inflammation business Research Paper |
| Zdroj: | Oncotarget |
| ISSN: | 1949-2553 |
| Popis: | // Ya-Ching Huang 1, 2, * , Hsiao-Chen Ning 1, 2, * , Shang-Syuan Chen 1 , Chia-Ni Lin 1, 2 , I-Kwan Wang 3 , Shu-Man Weng 4 , Cheng-Hao Weng 4 , Ching-Wei Hsu 4 , Wen-Hung Huang 4 , Jang-Jih Lu 1 , Tsu-Lan Wu 1, 2 and Tzung-Hai Yen 4, 5, 6 1 Department of Laboratory Medicine, Chang Gung Memorial Hospital, Linkou, Taiwan 2 Department of Medical Biotechnology and Laboratory Science, College of Medicine, Chang Gung University, Linkou, Taiwan 3 Department of Nephrology, Chang Medical University Hospital and College of Medicine, China Medical University, Taichung, Taiwan 4 Department of Nephrology, Chang Gung Memorial Hospital and College of Medicine, Chang Gung University, Linkou, Taiwan 5 Kidney Research Center, Chang Gung Memorial Hospital, Linkou, Taiwan 6 Center for Tissue Engineering, Chang Gung Memorial Hospital, Linkou, Taiwan * These authors have contributed equally to this work Correspondence to: Tzung-Hai Yen, email: m19570@adm.cgmh.org.tw Keywords: peritoneal dialysis, nickel, high sensitivity C-reactive protein, inflammation, inductively coupled plasma mass spectrometry Received: May 14, 2017 Accepted: June 30, 2017 Published: July 31, 2017 ABSTRACT This study surveyed urinary nickel concentrations in peritoneal dialysis (PD) patients, and analyzed the association of urinary nickel concentrations with clinical outcomes and inflammatory biomarkers. In total, 50 PD patients and 50 healthy controls were recruited for this study. All participants were examined for the presence of toxic trace elements (antimony, arsenic, bismuth, cadmium, copper, manganese, mercury, nickel, lead, tellurium, thallium and zinc) in their urine by using inductively coupled plasma mass spectrometry (ICP-MS). It was found that PD patients demonstrated higher urinary nickel concentrations than healthy controls (6.1±3.5 versus 2.8±1.4 μg/L, P 0.05). Thus, it is concluded that approximately half of the patients undergoing PD had elevated urinary nickel levels, and these patients also had elevated serum levels of high sensitivity C-reactive protein. Nevertheless, no other real correlations were discovered including no impact on patient outcome. Further studies are warranted. |
| Databáze: | OpenAIRE |
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