Parecoxib vs. lornoxicam in the treatment of postoperative pain after laparoscopic cholecystectomy: a prospective randomized placebo-controlled trial
| Autor: | Artemisia Papadima, Andreas Manouras, Vaggelogiannis Katergiannakis, F. Kremastinou, M. Pattas, Emmanuel Lagoudianakis, Pantelis T. Antonakis, L. Georgiou |
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| Rok vydání: | 2007 |
| Předmět: |
Male
medicine.medical_specialty Time Factors Meperidine Visual analogue scale medicine.medical_treatment Placebo-controlled study Placebo law.invention Placebos Piroxicam Randomized controlled trial law Parecoxib Lornoxicam medicine Humans Cyclooxygenase Inhibitors Prospective Studies Pain Measurement Pain Postoperative business.industry Anti-Inflammatory Agents Non-Steroidal Isoxazoles Middle Aged Equianalgesic Surgery Analgesics Opioid Treatment Outcome Anesthesiology and Pain Medicine Cholecystectomy Laparoscopic Elective Surgical Procedures Anesthesia Female Cholecystectomy business medicine.drug |
| Zdroj: | European Journal of Anaesthesiology. 24:154-158 |
| ISSN: | 0265-0215 |
| DOI: | 10.1017/s0265021506001293 |
| Popis: | Summary Background and objective: Non-steroidal anti-inflammatory drugs are considered as an effective treatment of postoperative pain after laparoscopic cholecystectomy. COX-2 inhibitors are newer drugs having less adverse effects. Data supporting their efficacy postoperatively in comparison to older non-steroidal anti-inflammatory drugs are scarce. Our study is a prospective, randomized, double-blinded, placebo-controlled trial comparing the efficacy of lornoxicam vs. parecoxib for the management of pain after laparoscopic cholecystectomy. Materials and methods: We enrolled 76 patients, ASA I and II, scheduled for elective laparoscopic cholecystectomy. The patients were randomized to receive before induction parecoxib 40 mg i.v., lornoxicam 8 mg i.v. or placebo. Pain at rest and on movement was assessed using a visual analogue scale at 0, 6, 12 h postoperatively. Total meperidine consumption and adverse effects were also recorded. Results: At 12 h, visual analogue scale scores at rest and on movement were significantly lower with parecoxib and lornoxicam compared with control ( P = 0.047). The percentage of patients needing meperidine and the average dose of meperidine administered was significantly lower with parecoxib and lornoxicam compared with control ( P P = 0.018). There was no difference between parecoxib and lornoxicam. One patient receiving lornoxicam vomited. Conclusions: Parecoxib 40 mg i.v. and lornoxicam 8 mg i.v. were equianalgesic and both were more efficacious than placebo for the management of pain after laparoscopic cholecystectomy. |
| Databáze: | OpenAIRE |
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