Anti-Mycobacterium tuberculosis activity of fungus Phomopsis stipata
| Autor: | Karina Andrade de Prince, Renata Sordi, Fernando Rogério Pavan, Adolfo Carlos Barreto Santos, Angela R. Araujo, Sergio R.A. Leite, Clarice Q. F. Leite |
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| Přispěvatelé: | Universidade Estadual Paulista (Unesp), Faculdades Integradas Pitágoras |
| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: | |
| Zdroj: | Brazilian Journal of Microbiology, Volume: 43, Issue: 1, Pages: 224-229, Published: MAR 2012 SciELO Repositório Institucional da UNESP Universidade Estadual Paulista (UNESP) instacron:UNESP Brazilian Journal of Microbiology, Vol 43, Iss 1, Pp 224-229 (2012) Brazilian Journal of Microbiology v.43 n.1 2012 Brazilian Journal of Microbiology Sociedade Brasileira de Microbiologia (SBM) instacron:SBM |
| ISSN: | 1517-8382 |
| Popis: | Submitted by Guilherme Lemeszenski (guilherme@nead.unesp.br) on 2013-08-22T18:41:32Z No. of bitstreams: 1 S1517-83822012000100024.pdf: 132915 bytes, checksum: a8d45353c46b3da558a29a48cbbf83e0 (MD5) Made available in DSpace on 2013-08-22T18:41:32Z (GMT). No. of bitstreams: 1 S1517-83822012000100024.pdf: 132915 bytes, checksum: a8d45353c46b3da558a29a48cbbf83e0 (MD5) Previous issue date: 2012-03-01 Made available in DSpace on 2013-09-30T19:28:06Z (GMT). No. of bitstreams: 2 S1517-83822012000100024.pdf: 132915 bytes, checksum: a8d45353c46b3da558a29a48cbbf83e0 (MD5) S1517-83822012000100024.pdf.txt: 23967 bytes, checksum: 96e4bcd49cda28ee908de97313a4d72a (MD5) Previous issue date: 2012-03-01 Submitted by Vitor Silverio Rodrigues (vitorsrodrigues@reitoria.unesp.br) on 2014-05-20T13:24:07Z No. of bitstreams: 2 S1517-83822012000100024.pdf: 132915 bytes, checksum: a8d45353c46b3da558a29a48cbbf83e0 (MD5) S1517-83822012000100024.pdf.txt: 23967 bytes, checksum: 96e4bcd49cda28ee908de97313a4d72a (MD5) Made available in DSpace on 2014-05-20T13:24:07Z (GMT). No. of bitstreams: 2 S1517-83822012000100024.pdf: 132915 bytes, checksum: a8d45353c46b3da558a29a48cbbf83e0 (MD5) S1517-83822012000100024.pdf.txt: 23967 bytes, checksum: 96e4bcd49cda28ee908de97313a4d72a (MD5) Previous issue date: 2012-03-01 Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) Our purpose was to determine the anti-Mycobacterium tuberculosis activity of the metabolites produced by the endophitic fungus Phomopsis stipata (Lib.) B. Sutton, (Diaporthaceae), cultivated in different media. The antimycobacterial activity was assessed through the Resazurin Microtiter Assay (REMA) and the cytotoxicity test performed on macrophage cell line. The extracts derived from fungi grown on Corn Medium and Potato Dextrose Broth presented the smallest values of Minimum Inhibitory Concentration (MIC) and low cytotoxicity, which implies a high selectivity index. This is the first report on the chemical composition and antitubercular activity of metabolites of P. stipata, as well as the influence of culture medium on these properties. Universidade Estadual Paulista Faculdades Integradas Pitágoras Universidade Estadual Paulista FAPESP: 11/11593-7 FAPESP: 08/10390-2 FAPESP: 06/50680 FAPESP: 09/06499-1 |
| Databáze: | OpenAIRE |
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