Overexpression of Adiponectin Improves Neurobehavioral Outcomes After Focal Cerebral Ischemia in Aged Mice

Autor:	Mei Xin Tao, Kunlin Jin, Yongting Wang, Guo-Yuan Yang, Yong Ju Zhao, Jie Miao, Yaohui Tang, Lin Hui Shen
Jazyk:	angličtina
Rok vydání:	2013
Předmět:	Male medicine.medical_specialty Aging animal structures Angiogenesis Ischemia Gene transfer Adenoviridae Brain Ischemia Mice Treated mouse Physiology (medical) Internal medicine Proliferating Cell Nuclear Antigen medicine Animals Pharmacology (medical) Middle cerebral artery occlusion Young adult Pharmacology Adiponectin business.industry Mental Disorders Age Factors Original Articles medicine.disease Platelet Endothelial Cell Adhesion Molecule-1 Psychiatry and Mental health Disease Models Animal Endocrinology medicine.anatomical_structure Gene Expression Regulation Anesthesia Phosphopyruvate Hydratase Microvessels business hormones hormone substitutes and hormone antagonists Blood vessel
Popis:	Summary Aims To study whether adiponectin (APN) could improve neurological outcomes in aged mice after ischemic stroke. Methods Adeno-associated virus carrying APN gene was injected into aged and young adult mice 7 days before transient middle cerebral artery occlusion (tMCAO). Atrophic volumes and neurobehavioral deficiencies were determined up to 28 days after tMCAO. Focal angiogenesis was determined based on blood vessel number in the ischemic regions. Results Increased atrophic volume and more sever neurobehavioral deficits were found in the aged mice compared with young adult mice (P
Databáze:	OpenAIRE
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