Light reintroduction after dark exposure reactivates plasticity in adults via perisynaptic activation of MMP-9
| Autor: | Murase, Sachiko, Lantz, Crystal L, Quinlan, Elizabeth M |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Mouse Light genetic structures QH301-705.5 Period (gene) extracellular matrix Science Biology Matrix (biology) Plasticity General Biochemistry Genetics and Molecular Biology Ocular dominance Extracellular matrix Mice 03 medical and health sciences ocular dominance plasticity 0302 clinical medicine Thalamus medicine Animals Visual Pathways Biology (General) Visual Cortex Mice Knockout Neuronal Plasticity General Immunology and Microbiology General Neuroscience aging General Medicine Anatomy Darkness Cell biology Cortex (botany) Monocular deprivation 030104 developmental biology Visual cortex medicine.anatomical_structure Matrix Metalloproteinase 9 Proteolysis Medicine 030217 neurology & neurosurgery Research Article Neuroscience |
| Zdroj: | eLife, Vol 6 (2017) eLife |
| Popis: | The sensitivity of ocular dominance to regulation by monocular deprivation is the canonical model of plasticity confined to a critical period. However, we have previously shown that visual deprivation through dark exposure (DE) reactivates critical period plasticity in adults. Previous work assumed that the elimination of visual input was sufficient to enhance plasticity in the adult mouse visual cortex. In contrast, here we show that light reintroduction (LRx) after DE is responsible for the reactivation of plasticity. LRx triggers degradation of the ECM, which is blocked by pharmacological inhibition or genetic ablation of matrix metalloproteinase-9 (MMP-9). LRx induces an increase in MMP-9 activity that is perisynaptic and enriched at thalamo-cortical synapses. The reactivation of plasticity by LRx is absent in Mmp9−/− mice, and is rescued by hyaluronidase, an enzyme that degrades core ECM components. Thus, the LRx-induced increase in MMP-9 removes constraints on structural and functional plasticity in the mature cortex. |
| Databáze: | OpenAIRE |
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