Biodegradable injectable polyurethanes: Synthesis and evaluation for orthopaedic applications
| Autor: | Tim Moore, Pathiraja A. Gunatillake, Raju Adhikari, Shadi Houshyar, Malsha Wickramaratna, Margaret A. McGee, Roshan T.M. Mayadunne, Lisa Tatai, Tania A. Carbone, Ian Griffiths, John R. Field |
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| Rok vydání: | 2008 |
| Předmět: |
Materials science
Biocompatibility Surface Properties Polyurethanes Biophysics Biocompatible Materials Bioengineering Pentaerythritol Injections Biomaterials chemistry.chemical_compound Implants Experimental Materials Testing Polymer chemistry Animals Lactic Acid Prepolymer Curing (chemistry) Glycolic acid chemistry.chemical_classification Bone growth Sheep Tissue Engineering Polymer Glycolates Polyester Orthopedics chemistry Chemical engineering Mechanics of Materials Ceramics and Composites |
| Zdroj: | Biomaterials. 29:3762-3770 |
| ISSN: | 0142-9612 |
| DOI: | 10.1016/j.biomaterials.2008.06.021 |
| Popis: | Biodegradable polyurethanes offer advantages in the design of injectable or preformed scaffolds for tissue engineering and other medical implant applications. We have developed two-part injectable prepolymer systems (prepolymer A and B) consisting of lactic acid and glycolic acid based polyester star polyols, pentaerythritol (PE) and ethyl lysine diisocyanate (ELDI). This study reports on the formulation and properties of a series of cross linked polyurethanes specifically developed for orthopaedic applications. Prepolymer A was based on PE and ELDI. Polyester polyols (prepolymer B) were based on PE and dl-lactic acid (PEDLLA) or PE and glycolic acid (PEGA) with molecular weights 456 and 453, respectively. Several cross linked porous and non-porous polyurethanes were prepared by mixing and curing prepolymers A and B and their mechanical and thermal properties, in vitro (PBS/37 degrees C/pH 7.4) and in vivo (sheep bi-lateral) degradation evaluated. The effect of incorporating beta-tricalcium phosphate (beta-TCP, 5 microns, 10 wt.%) was also investigated. The cured polymers exhibited high compressive strength (100-190 MPa) and modulus (1600-2300 MPa). beta-TCP improved mechanical properties in PEDLLA based polyurethanes and retarded the onset of in vitro and in vivo degradation. Sheep study results demonstrated that the polymers in both injectable and precured forms did not cause any surgical difficulties or any adverse tissue response. Evidence of new bone growth and the gradual degradation of the polymers were observed with increased implant time up to 6 months. |
| Databáze: | OpenAIRE |
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