Naturally Occurring Human Monoclonal Antibodies Neutralize both 1918 and 2009 Pandemic Influenza A (H1N1) Viruses

Autor:	Rong Hai, Chelsey J. Huffman, Patricia A. McGraw, Terrence M. Tumpey, James E. Crowe, Jens C. Krause, Melissa B. Pearce, Christopher F. Basler, Tshidi Tsibane
Rok vydání:	2010
Předmět:	Swine medicine.drug_class viruses Molecular Sequence Data Immunology Orthomyxoviridae Hemagglutinin Glycoproteins Influenza Virus Monoclonal antibody medicine.disease_cause Microbiology H5N1 genetic structure Antigenic drift Virus Cell Line Disease Outbreaks Influenza A Virus H1N1 Subtype Orthomyxoviridae Infections Neutralization Tests Virology Influenza Human medicine Influenza A virus Animals Humans Amino Acid Sequence Original antigenic sin Antigens Viral biology Antibodies Monoclonal biology.organism_classification Antibodies Neutralizing Insect Science biology.protein Pathogenesis and Immunity Antibody Sequence Alignment
Zdroj:	Journal of Virology. 84:3127-3130
ISSN:	1098-5514 0022-538X
Popis:	The 2009 pandemic influenza A (H1N1) virus exhibits hemagglutinin protein sequence homology with the 1918 pandemic influenza virus. We found that human monoclonal antibodies recognized the Sa antigenic site on the head domains of both 1918 and 2009 hemagglutinins, a site that is hypervariable due to immune selection. These antibodies exhibited high potency against the 2009 virusin vitro, and one exerted a marked therapeutic effectin vivo.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de066486c06ef943ceacf43a3a1ad8a3 https://doi.org/10.1128/jvi.02184-09 Zobrazit plný text záznamu