Incremental prognostic value of myocardial neuroadrenergic damage in patients with chronic congestive heart failure: An iodine-123 meta-iodobenzylguanidine scintigraphy study
| Autor: | Spinnler Maria Teresa, Scrima Giovanni, Dellavesa Pierfranco, Gambino Alfonso, Bertuccio Giovanni, Maffè Stefano, Canavese Giacomo, Marcassa Claudio, Campini Riccardo, Paffoni Paola, Parravicini Umberto, Cannillo Margherita |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
Male medicine.medical_specialty Disease 030204 cardiovascular system & hematology Scintigraphy Risk Assessment 030218 nuclear medicine & medical imaging Sudden cardiac death Iodine Radioisotopes 03 medical and health sciences 0302 clinical medicine Predictive Value of Tests Internal medicine Iodine-123 medicine Humans Radiology Nuclear Medicine and imaging In patient Radionuclide Imaging Aged Retrospective Studies Aged 80 and over Heart Failure Ejection fraction medicine.diagnostic_test business.industry Patient Selection Middle Aged Prognosis medicine.disease Defibrillators Implantable 3-Iodobenzylguanidine Heart failure Chronic Disease Cardiology Female Radiopharmaceuticals Cardiology and Cardiovascular Medicine business Mace |
| Zdroj: | Journal of Nuclear Cardiology. 27:1787-1797 |
| ISSN: | 1532-6551 1071-3581 |
| Popis: | ICD in primary prevention reduced mortality in patients with heart failure (HF); however, in about 80% of the ICD recipients an event requiring a device intervention will never occur. Thus, a reliable screening test included in a multiparametric approach to appropriately select patients to ICD implantation is increasingly required. Aim of the work was to assess if the Iodine-123 Meta-Iodobenzylguanidine scintigraphy (123I-mIBG) could be useful to identify patients with HF who would not benefit from the ICD implantation because at low risk of arrhythmias. This is a retrospective multicentre study on patients undergoing 123I-mIBG from February 2012 to December 2015. Inclusion criteria where: age ≥ 18 years old, LVEF ≤ 35% with idiopathic or ischemic heart disease, no previous malignant ventricular arrhythmias. Patients were divided in two groups based on of late H/M < or ≥ 1.60 on 123I-mIBG. Primary end-point was occurrence of malignant arrhythmias. Secondary end-point was occurrence of cardiac death and hospitalization for worsening HF. MACE were mortality and malignant arrhythmias. Eighty-one patients were enrolled (mean age: 69 years). On 123I-mIBG, 54 patients had late H/M |
| Databáze: | OpenAIRE |
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