Are There Mutator Polymerases?
| Autor: | José F. Ruiz, Raquel Juárez, Luis Blanco, Gloria Terrados, Miguel Garcia-Diaz |
|---|---|
| Přispěvatelé: | Universidad de Sevilla. Departamento de Bioquímica Vegetal y Biología Molecular |
| Jazyk: | angličtina |
| Rok vydání: | 2003 |
| Předmět: |
DNA repair
DNA polymerase lcsh:Medicine Somatic hypermutation Review Article DNA-Directed DNA Polymerase lcsh:Technology Genome General Biochemistry Genetics and Molecular Biology lcsh:Science Polymerase General Environmental Science Genetics chemistry.chemical_classification biology lcsh:T lcsh:R Mutagenesis General Medicine tranlesion synthesis VDJ recombination Low fidelity somatic hypermutation Models Structural Enzyme chemistry Tranlesion synthesis biology.protein lcsh:Q |
| Zdroj: | The Scientific World Journal Scopus-Elsevier The Scientific World Journal, Vol 3, Pp 422-431 (2003) idUS. Depósito de Investigación de la Universidad de Sevilla instname |
| ISSN: | 1537-744X 2356-6140 |
| Popis: | DNA polymerases are involved in different cellular events, including genome replication and DNA repair. In the last few years, a large number of novel DNA polymerases have been discovered, and the biochemical analysis of their properties has revealed a long list of intriguing features. Some of these polymerases have a very low fidelity and have been suggested to play mutator roles in different processes, like translesion synthesis or somatic hypermutation. The current view of these processes is reviewed, and the current understanding of DNA polymerases and their role as mutator enzymes is discussed. |
| Databáze: | OpenAIRE |
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