Recent Updates and Advances in the Use of Glycated Albumin for the Diagnosis and Monitoring of Diabetes and Renal, Cerebro- and Cardio-Metabolic Diseases
| Autor: | Rosanna Maniscalco, Luisa Agnello, Giulia Bivona, Daniela Ligi, Rosaria Vincenza Giglio, Bruna Lo Sasso, Ferdinando Mannello, Marcello Ciaccio |
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| Přispěvatelé: | Giglio, RV, Lo Sasso, B, Agnello, L, Bivona, G, Maniscalco, R, Ligi, D, Mannello, F, Ciaccio, M |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
obesity kidney disease glycated albumin cerebrovascular disease diabetes dyslipidemia obesity kidney disease therapy cardiovascular disease lcsh:Medicine 030209 endocrinology & metabolism Disease Review 030204 cardiovascular system & hematology Nephropathy 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine cardiovascular disease Internal medicine Diabetes mellitus Medicine Glycemic therapy diabetes business.industry lcsh:R dyslipidemia General Medicine cerebrovascular disease glycated albumin medicine.disease chemistry Biomarker (medicine) Glycated hemoglobin business Dyslipidemia Kidney disease |
| Zdroj: | Journal of Clinical Medicine Journal of Clinical Medicine, Vol 9, Iss 3634, p 3634 (2020) |
| ISSN: | 2077-0383 |
| Popis: | Diabetes mellitus is a heterogeneous and dysmetabolic chronic disease in which the laboratory plays a fundamental role, from diagnosis to monitoring therapy and studying complications. Early diagnosis and good glycemic control should start as early as possible to delay and prevent metabolic and cardio-vascular complications secondary to this disease. Glycated hemoglobin is currently used as the reference parameter. The accuracy of the glycated hemoglobin dosage may be compromised in subjects suffering from chronic renal failure and terminal nephropathy, affected by the reduction in the survival of erythrocytes, with consequent decrease in the time available for glucose to attach to the hemoglobin. In the presence of these renal comorbidities as well as hemoglobinopathies and pregnancy, glycated hemoglobin is not reliable. In such conditions, dosage of glycated albumin can help. Glycated albumin is not only useful for short-term diagnosis and monitoring but predicts the risk of diabetes, even in the presence of euglycemia. This protein is modified in subjects who do not yet have a glycemic alteration but, as a predictive factor, heralds the risk of diabetic disease. This review summarizes the importance of glycated albumin as a biomarker for predicting and stratifying the cardiovascular risk linked to multiorgan metabolic alterations. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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