The predictive value of liver fibrosis in determining the effectiveness of interferon and lamivudine therapies for chronic hepatitis B
| Autor: | Tadao Okuno, Kazushige Hamada, Kenichi Nishioji, Michiko Shindo, Yoko Oda, Akira Muramatsu |
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| Rok vydání: | 2003 |
| Předmět: |
Adult
Liver Cirrhosis Male medicine.medical_specialty Hepatitis B virus Drug resistance Gastroenterology Antiviral Agents Hepatitis B Chronic Methionine Surgical oncology Interferon Predictive Value of Tests Internal medicine Drug Resistance Viral medicine Humans Hepatitis B e Antigens Retrospective Studies Aspartic Acid business.industry Lamivudine Interferon-alpha Retrospective cohort study Alanine Transaminase Hepatitis B Hepatology Middle Aged medicine.disease Virology Treatment Outcome Predictive value of tests DNA Viral Mutation Tyrosine Female business medicine.drug |
| Zdroj: | Journal of gastroenterology. 39(3) |
| ISSN: | 0944-1174 |
| Popis: | To determine the best indicator of the effective use of interferon and lamivudine for the treatment of hepatitis B e antigen-positive chronic hepatitis, we retrospectively analyzed histologic and virologic status in 200 patients who were treated with interferon and 45 patients who were treated with lamivudine.Histological grading and staging scores were determined by international criteria and the METAVIR scoring system. The YMDD motif associated with lamivudine resistance was analyzed by the sequencing of hepatitis B virus (HBV) DNA.Of 200 interferon-treated patients, 62 (31%) seroconverted to anti-hepatitis B e (anti-HBe). Multivariate analysis showed that the significantly important predictors of response were a higher grading score (P = 0.0056) and lower staging score (P = 0.0010). Twenty (44%) of the 45 lamivudine-treated patients seroconverted to anti-HBe, and multivariate analysis showed that the significantly important predictors of response were a higher alanine aminotransferase (ALT) level (P = 0.0034) and lower hepatitis B e antigen levels ( P = 0.0128). YMDD mutations occurred during therapy in 12 patients (27%). The significantly important predictor of the development of mutation was a higher staging score (P = 0.0226).Both interferon and lamivudine were effective for patients with high ALT levels, but interferon's efficacy appeared to be limited by the degree of fibrosis. Lamivudine appeared to be effective irrespective of the degree of fibrosis, but YMDD mutations seemed to develop sooner in patients with advanced liver fibrosis. |
| Databáze: | OpenAIRE |
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