Novel cardiac cell subpopulations: Pnmt-derived cardiomyocytes
| Autor: | Ming Lei, Alexander Grassam-Rowe, Xianghong Ou |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
phenylethanolamine n-methyl transferase
Organogenesis Cellular differentiation Cell Plasticity Immunology Adrenergic Review Review Article 030204 cardiovascular system & hematology Biology General Biochemistry Genetics and Molecular Biology Cardiac cell cardiac cellular subpopulations 03 medical and health sciences Catecholamines 0302 clinical medicine Parenchyma Animals Humans Transferase Myocytes Cardiac lcsh:QH301-705.5 030304 developmental biology 0303 health sciences Myocardium Phenylethanolamine N-Methyltransferase General Neuroscience Age Factors pnmt pdcms Pathophysiology Electrophysiological Phenomena cardiac adrenergic signalling Phenotype lcsh:Biology (General) pnmt-derived cardiomyocytes Neuroscience Biomarkers Function (biology) |
| Zdroj: | Open Biology, Vol 10, Iss 8 (2020) Open Biology |
| ISSN: | 2046-2441 |
| DOI: | 10.1098/rsob.200095 |
| Popis: | Diversity among highly specialized cells underlies the fundamental biology of complex multi-cellular organisms. One of the essential scientific questions in cardiac biology has been to define subpopulations within the heart. The heart parenchyma comprises specialized cardiomyocytes (CMs). CMs have been canonically classified into a few phenotypically diverse subpopulations largely based on their function and anatomic localization. However, there is growing evidence that CM subpopulations are in fact numerous, with a diversity of genetic origin and putatively different roles in physiology and pathophysiology. In this chapter, we introduce a recently discovered CM subpopulation: phenylethanolamine- N -methyl transferase (Pnmt)-derived cardiomyocytes (PdCMs). We discuss: (i) canonical classifications of CM subpopulations; (ii) discovery of PdCMs; (iii) Pnmt and the role of catecholamines in the heart; similarities and dissimilarities of PdCMs and canonical CMs; and (iv) putative functions of PdCMs in both physiological and pathological states and future directions, such as in intra-cardiac adrenergic signalling. |
| Databáze: | OpenAIRE |
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