Chiral separation and absolute configurations of two pairs of racemic polyprenylated benzophenones from Hypericum sampsonii
| Autor: | Xiao-Jie Jin, Xiao-Jun Yao, Yi Dai, Wen-Jing Tian, Xin-Sheng Yao, Yu-Qin Qiu, Hai-Feng Chen |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Prenylation
Pharmacology Quantum chemical Retinoid X Receptor alpha Molecular Structure Transcription Genetic biology 010405 organic chemistry Chemistry Stereochemistry Hypericum sampsonii General Medicine Plant Components Aerial Crystallography X-Ray 010402 general chemistry biology.organism_classification 01 natural sciences 0104 chemical sciences Chiral column chromatography Benzophenones Drug Discovery Humans Hypericum HeLa Cells |
| Zdroj: | Fitoterapia. 116:39-44 |
| ISSN: | 0367-326X |
| DOI: | 10.1016/j.fitote.2016.10.014 |
| Popis: | (±) Sampsonins A-B (1-2), two pairs of racemic polyprenylated benzophenones, were isolated from the aerial parts of Hypericum sampsonii and successfully separated by chiral HPLC column. Their structures were elucidated by spectroscopic analyses, X-ray diffraction analysis, and quantum chemical calculation of ECD method. Besides, the plausible biogenetic pathways of 1-2 were proposed, and all of them were evaluated for RXRα transcriptional-inhibitory activities and cytotoxicity against HeLa cells. |
| Databáze: | OpenAIRE |
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