UNKNOWN AND ALREADY KNOWN THYROID ABNORMALITIES IN PRIMARY HYPERPARATHYROIDISM
| Autor: | Flora Cesario, Roberto Attanasio, Elena Castellano, Giorgio Borretta, Adele Latina, Alberto Boriano |
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| Rok vydání: | 2018 |
| Předmět: |
endocrine system diseases
Endocrinology Diabetes and Metabolism Population Parathyroid hormone 030209 endocrinology & metabolism Bioinformatics 03 medical and health sciences 0302 clinical medicine Endocrinology Medicine Humans education Retrospective Studies education.field_of_study Hyperparathyroidism business.industry Thyroid General Medicine Thyroid abnormalities medicine.disease Hyperparathyroidism Primary Thyroid Diseases medicine.anatomical_structure Parathyroid Hormone 030220 oncology & carcinogenesis Calcium Female business Primary hyperparathyroidism |
| Zdroj: | Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists. 24(7) |
| ISSN: | 1530-891X |
| Popis: | Primary hyperparathyroidism (PHPT) and thyroid diseases are highly prevalent in the general population, but the putative link between the 2 conditions remains unclear.A monocentric consecutive series of 434 patients with PHPT was retrospectively evaluated by lab and ultrasonography to look for thyroid abnormalities. Patients were classified in 3 groups: without thyroid abnormalities (group 1, n = 171), with thyroid diseases not previously known (group 2a, n = 69), and thyroid diseases previously known (group 2b, n = 194).In terms of thyroid disease, no significant difference was found between groups 2a and 2b, except for the significantly larger number of patients with toxic nodular goiter in group 2b. PHPT was more frequently symptomatic in group 2a than in group 2b, despite no differences in serum calcium, creatinine, parathyroid hormone (PTH), or 25-hydroxyvitamin D (25OHD) levels.A total of 60% of PHPT patients had a thyroid disease that was unknown prior to PHPT diagnosis in almost one-third of cases. The newly diagnosed and previously known thyroid diseases were similar, both mostly affecting postmenopausal females.Ab = antibody; aPHPT = asymptomatic PHPT; 25OHD = 25-hydroxyvitamin D; PHPT = primary hyperparathyroidism; PTH = parathyroid hormone; Tg = thyroglobulin; TPO = thyroperoxidase; TSH = thyroid-stimulating hormone; US = ultrasound. |
| Databáze: | OpenAIRE |
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