MicroRNA in breast cancer: The association with BRCA1/2
| Autor: | Nina Petrović, R. Esma Isenovic, Vladan Bajic, Milan Obradovic, Radoslav Davidovic |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Oncology Cancer Research medicine.medical_specialty DNA repair medicine.medical_treatment Breast Neoplasms Disease Synthetic lethality Targeted therapy 03 medical and health sciences 0302 clinical medicine Breast cancer Internal medicine microRNA Genetics medicine Biomarkers Tumor Gene silencing Humans skin and connective tissue diseases miRNA BRCA2 Protein business.industry BRCA1 Protein General Medicine medicine.disease BRCA1 BRCA2 3. Good health Gene Expression Regulation Neoplastic MicroRNAs 030104 developmental biology 030220 oncology & carcinogenesis Female business TNBC |
| Zdroj: | Cancer Biomarkers |
| ISSN: | 1875-8592 |
| Popis: | Breast cancer (BC) is a heterogeneous disease in an urgent need for developing novel research, classification, and therapy approaches. Breast cancer 1 (BRCA1) and breast cancer 2 (BRCA2) proteins are well described tumor suppressors with great potential to be the subjects of different therapies. MicroRNAs (miRNAs) are genetic elements that might be used to solve the complex BC puzzle. BRCA1 was described to be the target of up to 100 miRNAs. BRCA1 may directly repress miR-155 activity. In addition, miR-15/107/182-mediated downregulation of BRCA1 interrupt DNA repair and may change the course of BC therapy. miR-146a and miR-146-5p silencing BRCA1 may trigger formation of triple-negative and basal-like sporadic BC cases. miR-182 might effect the therapy outcome. miR-21 targeted therapy might be useful for the treatment of BRCA2 mutation carriers. miR-342 overexpression and the absence of functional BRCA1 gene might cause synthetic lethality, which might be used as a base for future therapies. The present review discusses the latest data from studies that focus on the complex network of miRNAs and BRCA1/2 related BCs, which might be important for improving the therapy within the patients with triple-negative BC (TNBC) and basal-like BC, and for understanding the formation of TNBC. |
| Databáze: | OpenAIRE |
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