Abnormal metabolic network activity in REM sleep behavior disorder
| Autor: | Andrew Feigin, David Eidelberg, Jean-François Gagnon, Vijay Dhawan, Florian Holtbernd, Mélanie Vendette, Ronald B. Postuma, Jean-Paul Soucy, Yilong Ma, Jacques Montplaisir, Chris C. Tang |
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| Rok vydání: | 2014 |
| Předmět: |
Lewy Body Disease
medicine.medical_specialty Pathology Perfusion scanning REM Sleep Behavior Disorder Multimodal Imaging REM sleep behavior disorder Gastroenterology Article Neuroimaging Fluorodeoxyglucose F18 Predictive Value of Tests Internal medicine medicine Humans Single-Blind Method Aged Tomography Emission-Computed Single-Photon medicine.diagnostic_test Parkinson Disease Middle Aged medicine.disease Control subjects Positron emission tomography Positron-Emission Tomography Predictive value of tests Cohort Neurology (clinical) Tomography X-Ray Computed Psychology Follow-Up Studies Cohort study |
| Zdroj: | Neurology. 82:620-627 |
| ISSN: | 1526-632X 0028-3878 |
| DOI: | 10.1212/wnl.0000000000000130 |
| Popis: | To determine whether the Parkinson disease-related covariance pattern (PDRP) expression is abnormally increased in idiopathic REM sleep behavior disorder (RBD) and whether increased baseline activity is associated with greater individual risk of subsequent phenoconversion.For this cohort study, we recruited 2 groups of RBD and control subjects. Cohort 1 comprised 10 subjects with RBD (63.5 ± 9.4 years old) and 10 healthy volunteers (62.7 ± 8.6 years old) who underwent resting-state metabolic brain imaging with (18)F-fluorodeoxyglucose PET. Cohort 2 comprised 17 subjects with RBD (68.9 ± 4.8 years old) and 17 healthy volunteers (66.6 ± 6.0 years old) who underwent resting brain perfusion imaging with ethylcysteinate dimer SPECT. The latter group was followed clinically for 4.6 ± 2.5 years by investigators blinded to the imaging results. PDRP expression was measured in both RBD groups and compared with corresponding control values.PDRP expression was elevated in both groups of subjects with RBD (cohort 1: p0.04; cohort 2: p0.005). Of the 17 subjects with long-term follow-up, 8 were diagnosed with Parkinson disease or dementia with Lewy bodies; the others did not phenoconvert. For individual subjects with RBD, final phenoconversion status was predicted using a logistical regression model based on PDRP expression and subject age at the time of imaging (r(2) = 0.64, p0.0001).Latent network abnormalities in subjects with idiopathic RBD are associated with a greater likelihood of subsequent phenoconversion to a progressive neurodegenerative syndrome. |
| Databáze: | OpenAIRE |
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